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1,364 research outcomes, page 1 of 137
  • publication . Article . 2012
    Open Access English
    Authors:
    Andrea Doeschl-Wilson; Steve C. Bishop; Ilias Kyriazakis; Beatriz Villanueva;
    Publisher: Frontiers Media S.A.

    We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group toleranc...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Mursal Sherzai; Adamo Valle; Nicholas J. S. Perry; Ester Kalef-Ezra; Sahar Al-Mahdawi; Mark A. Pook; Sara Anjomani Virmouni;
    Persistent Identifiers
    Publisher: Frontiers Media

    Copyright © 2020 Sherzai, Valle, Perry, Kalef-Ezra, Al-Mahdawi, Pook and Anjomani Virmouni. Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigat...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Armamento-Villareal, Reina; Shah, Vallabh O.; Aguirre, Lina E.; Meisner, Angela L. W.; Qualls, Clifford; Royce, Melanie E.;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: NIH | New Mexico IDeA Networks ... (8P20GM103451-12), NIH | INVESTIGATION OF DEGRADAT... (5P20RR016480-07)

    Given the racial/ethnic disparities in breast cancer, we evaluated the association between CYP19A1 single nucleotide polymorphisms (SNPs) on disease progression in women with breast cancer from different racial/ethnic backgrounds. This is a cross-sectional analysis of d...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Jessica Duis; Olivia Cox; Yuelong Ji; Fayaz Seifuddin; Richard S. Lee; Xiaobin Wang;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: NIH | Gene Polymorphism, Infect... (7R01HD041702-04), NIH | Molecular Epidemiology of... (5R21ES011666-02), NIH | Epigenome-wide Associatio... (7R21HD066471-02)

    A single nucleotide polymorphism (SNP: rs1360780) in FKBP5 (FK506 Binding Protein 5) has been shown to interact with exposure to childhood adversity to promote loss of methylation and increase in gene expression in adults. We asked whether rs1360780 can influence FKBP5 ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    You Cai; Yufen Zhang; Xiao Ke; Yu Guo; Chengye Yao; Na Tang; Pei Pang; Gangcai Xie; Li Fang; Zhe Zhang; ...
    Persistent Identifiers
    Publisher: Frontiers Media S.A.

    Ischemic stroke, which accounts for 87% of all strokes, constitutes the leading cause of morbidity and mortality in China. Although the genetics and epigenetics of stroke have been extensively investigated, few studies have examined their relationships at different stag...

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  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Serge Nataf; Juan Uriagereka; Antonio Benítez-Burraco;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>ABSTRACT</jats:title><jats:p>Social behavior and neuronal connectivity in rodents have been shown to be shaped by the prototypical T lymphocyte-derived pro-inflammatory cytokine Interferon-gamma (IFNγ). It has also been demonstrated that STAT1 (Signal Transd...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Charmaine S. Tam; Jeffrey D. Covington; Eric Ravussin; Leanne M. Redman;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: NIH | Effects of weight and ins... (5K99HD060762-02), NIH | Metabolic Adaptations to ... (3U01AG020478-06S1), NIH | Core--Molecular Mechanism... (5P30DK072476-05)

    Context: The effect of weight loss by diet alone or diet in conjunction with exercise on low-grade inflammation in non-obese (overweight) individuals is not known. Objective: Test the hypothesis that 24 weeks of moderate calorie restriction (CR; 25%) by diet only or wit...

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  • publication . Article . 2015
    Open Access
    Authors:
    Georg Basler; Evangelos Simeonidis;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: EC | PSEUDOMODEL (329682)

    Peer reviewed

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Megan K. Mulligan; Wenyuan Zhao; Morgan Dickerson; Danny Arends; Pjotr Prins; Sonia A. Cavigelli; Elena Terenina; Pierre Mormède; Lu Lu; Byron C. Jones;
    Publisher: HAL CCSD
    Project: NIH | Genetic Analysis of Ethan... (5U01AA014425-02), NIH | Genetics of Chronic Mild ... (5R01AA021951-03)

    International audience; We profiled individual differences in alcohol consumption upon initial exposure and during 5 weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains and parents using the drinking in the dark (DID) method. In this ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Monika Krzak; Yordan P. Raykov; Alexios Boukouvalas; Luisa Cutillo; Claudia Angelini;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | INCIPIT (665403)

    Single-cell RNA-seq (scRNAseq) is a powerful tool to study heterogeneity of cells. Recently, several clustering based methods have been proposed to identify distinct cell populations. These methods are based on different statistical models and usually require to perform...

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1,364 research outcomes, page 1 of 137