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317 research outcomes, page 1 of 32
  • publication . Article . 2012
    Open Access English
    Authors:
    Andrea Doeschl-Wilson; Steve C. Bishop; Ilias Kyriazakis; Beatriz Villanueva;
    Publisher: Frontiers Media S.A.

    We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group toleranc...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Mursal Sherzai; Adamo Valle; Nicholas J. S. Perry; Ester Kalef-Ezra; Sahar Al-Mahdawi; Mark A. Pook; Sara Anjomani Virmouni;
    Persistent Identifiers
    Publisher: Frontiers Media

    Copyright © 2020 Sherzai, Valle, Perry, Kalef-Ezra, Al-Mahdawi, Pook and Anjomani Virmouni. Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigat...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Monika Krzak; Yordan P. Raykov; Alexios Boukouvalas; Luisa Cutillo; Claudia Angelini;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | INCIPIT (665403)

    Single-cell RNA-seq (scRNAseq) is a powerful tool to study heterogeneity of cells. Recently, several clustering based methods have been proposed to identify distinct cell populations. These methods are based on different statistical models and usually require to perform...

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  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Ramadan, Kristijan; Dikic, Ivan;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: UKRI | Molecular insights into u... (MC_PC_12001/1)
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  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Cusanelli, Emilio; Chartrand, Pascal;
    Publisher: Frontiers Media S.A.
    Project: EC | INDICAR (609431), CIHR

    Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from degradation and activation of DNA damage response. For this reason, telomeres are essential to genome integrity. Chromosome ends are enriched in heterochromatic marks and proper org...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Webb, Bradley T.; Edwards, Alexis C.; Wolen, Aaron R.; Salvatore, Jessica E.; Aliev, Fazil; Riley, Brien P.; Sun, Cuie; Williamson, Vernell S.; Kitchens, James N.; Pedersen, Kimberly; ...
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: NIH | Integrating Genetics, Bra... (5F31AA024380-02), NIH | Pathways to Alcohol Use D... (5R01AA018333-05), WT | The Avon Longitudinal Stu... (102215), NIH | Genetic influences on dev... (4K01AA021399-05), UKRI | Alcohol Misuse: Electroni... (ES/L015471/1), WT , UKRI | Excessive drinking and al... (MR/L022206/1), NIH | Center for Clinical and T... (8UL1TR000058-03), NIH | Genetics, Romantic Relati... (5K01AA024152-02), NIH | Cross-Species Investigati... (5P50AA022537-03),...

    Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. Methods...

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  • publication . Article . Report . 2015
    Open Access English
    Authors:
    Brito, Sara; Thompson, Kyle; Campistol Plana, Jaume; Colomer, Jaume; Hardy, Steven A.; Langping, He; Fernández Marmiesse, Ana; Palacios, Lourdes; Jou, Cristina; Jiménez Mallebrera, Cecilia; ...
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: WT | Mitochondrial DNA - expre... (096919), UKRI | MRC Centre for Neuromuscu... (G0601943)

    BACKGROUND: Mitochondrial diseases due to deficiencies in the mitochondrial oxidative phosphorylation system (OXPHOS) can be associated with nuclear genes involved in mitochondrial translation, causing heterogeneous early onset and often fatal phenotypes. CASE REPORT: T...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Li, L; Kabesch, M; Bouzigon, E; Demenais, F; Farrall, M; Moffatt, MF; Lin, X; Liang, L;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: NIH | STATISTICAL METHODS FOR G... (5P01CA134294-02), WT | Understanding the genetic... (090532), NIH | Statistical Methods for C... (5R37CA076404-14)

    Increasing evidence suggests that single nucleotide polymorphisms (SNPs) associated with complex traits are more likely to be expression quantitative trait loci (eQTLs). Incorporating eQTL information hence has potential to increase power of genome-wide association stud...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Qian, Chaoju; Yan, Xia; Yin, Hengxia; Fan, Xingke; Yin, Xiaoyue; Sun, Peipei; Li, Zhijun; Nevo, Eviatar; Ma, Xiao-Fei;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.

    As one of the hotspot regions for sympatric speciation studies, Evolution Canyon (EC) became an ideal place for its high level of microclimatic divergence interslopes. In this study, to highlight the genetic mechanisms of sympatric speciation, phenotypic variation on fl...

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  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Armstrong, Kate E.; Stone, Graham N.; Nicholls, James A.; Valderrama, Eugenio; Anderberg, Arne A.; Smedmark, Jenny; Gautier, Laurent; Naciri, Yamama; Milne, Richard; Richardson, James E.;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Add to ORCID
317 research outcomes, page 1 of 32