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82,076 research outcomes, page 1 of 8,208
  • publication . Preprint . 2019
    Open Access
    Authors:
    Lee, Jessica A.; Stolyar, Sergey; Marx, Christopher J.;
    Persistent Identifiers
    Publisher: bioRxiv
    Project: NSF | Dimensions: The roles of ... (1831838)

    AbstractMicroorganisms faces many barriers in the degradation of the polycyclic aromatic polymer lignin, one of which is an abundance of methoxy substituents. Demethoxylation of lignin-derived aromatic monomers in aerobic environments releases formaldehyde, a potent cel...

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  • publication . Preprint . 2019
    Open Access English
    Authors:
    Sanaye, Sushant; Khandeparker, Rakhee; Sreepada, Rayadurga Anantha; Shivaramu, Mamatha Singanahalli; Kankonkar, Harshada; Narvekar, Jayu; Gauthankar, Mukund;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractAccurate information of taxonomy and geographic range of seahorse species (genus Hippocampus) is the first step in preparing threat assessments and designing effective conservation measures. Here, we report the range expansion and first occurrence of the Japanes...

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  • publication . Preprint . 2019
    Open Access
    Authors:
    Mostofa Rafid Uddin; Sazan Mahbub; M. S. Rahman; Md. Shamsuzzoha Bayzid;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractMotivationProtein structures provide basic insight into how they can interact with other proteins, their functions and biological roles in an organism. Experimental methods (e.g., X-ray crystallography, nuclear magnetic resonance spectroscopy) for predicting the...

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  • publication . Preprint . Article . 2016
    Open Access
    Authors:
    Changbong Hyeon; Dave Thirumalai;
    Publisher: Cold Spring Harbor Laboratory

    Using force as a probe to map the folding landscapes of RNA molecules has become a reality thanks to major advances in single molecule pulling experiments. Although the unfolding pathways under tension are complicated to predict studies in the context of proteins have s...

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  • publication . Preprint . Article . 2017
    Open Access English
    Authors:
    Diana Balasubramanian; John F. Pearson; Martin A. Kennedy;
    Publisher: Cold Spring Harbor Laboratory

    AbstractValproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat seroton...

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  • publication . Preprint . 2018
    Open Access English
    Authors:
    Stefania Sarno; Manuel Beiran; J. D. Vergara; Román Rossi-Pool; Ranulfo Romo; Néstor Parga;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractDopamine neurons produce reward-related signals that regulate learning and guide behavior. Prior expectations about forthcoming stimuli and internal biases can alter perception and choices and thus could influence dopamine signaling. We tested this hypothesis st...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Neuwald, Andrew F.; Altschul, Stephen F.;
    Publisher: Public Library of Science
    Project: NIH | Advanced correlation anal... (5R01GM125878-02)

    Protein Direct Coupling Analysis (DCA), which predicts residue-residue contacts based on covarying positions within a multiple sequence alignment, has been remarkably effective. This suggests that there is more to learn from sequence correlations than is generally assum...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Edelman, Nathaniel,; Frandsen, Paul,; Miyagi, Michael; Clavijo, Bernardo; Davey, John; Dikow, Rebecca,; García-Accinelli, Gonzalo; Van Belleghem, Steven,; Patterson, Nick; Neafsey, Daniel,; ...
    Publisher: bioRxiv
    Countries: United Kingdom, United Kingdom, Colombia, France
    Project: NIH | Characterizing the Molecu... (5R01GM108626-03), NIH | Large Scale Sequencing an... (3U54HG003067-07S1), NIH | Whole-genome shotgun sequ... (2R01HG003474-06A1), UKRI | BBR GenomeHubs - agile ge... (BB/R015325/1), NSERC , NIH | Genomic Center for Infect... (5U19AI110818-02), NSF | CAREER: The Molecular Bas... (1452648), NSF | Graduate Research Fellows... (1745303), ANR | HybEvol (ANR-12-JSV7-0005), NIH | Project 1: Modeling tumor... (1U54CA193313-01),...

    We here pioneer a low-cost assembly strategy for 20 Heliconiini genomes to characterize the evolutionary history of the rapidly radiating genus Heliconius. A bifurcating tree provides a poor fit to the data, and we therefore explore a reticulate phylogeny for Heliconius...

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  • publication . Preprint . 2018
    Open Access English
    Authors:
    Tuan Trieu; Oluwatosin Oluwadare; Jianlin Cheng;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NSF | CAREER: Analysis, Constru... (1149224)

    Eukaryotic chromosomes are often composed of components organized into multiple scales, such as nucleosomes, chromatin fibers, topologically associated domains (TAD), chromosome compartments, and chromosome territories. Therefore, reconstructing detailed 3D models of ch...

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  • publication . Preprint . 2020
    Open Access English
    Authors:
    Meaghan Marohn; Meng-ju Lin; Wei-wen Yu; Ciara Mae Mendoza; Juliana Remark; Alireza Khodadadi-Jamayran; Ernest S. Chiu; Catherine P. Lu;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Multispectral imaging & a... (1S10OD021747-01), NIH | Experimental Pathology (5P30CA016087-32)

    AbstractHidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease affecting human apocrine sweat gland-bearing skin regions. One unique feature of HS is the development of keratinized sinus tracts that grow extensively deep in the dermis and are highly...

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82,076 research outcomes, page 1 of 8,208