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26 research outcomes, page 1 of 3
  • publication . Article . 2017
    Open Access English
    Authors:
    Fernando De Castro; Roberto Maggi; Pedro Esteban; Ruth Seal;
    Publisher: Oxford University Press
    Project: WT , NIH | Nomenclature of Human and... (2U41HG003345-09), WT | The Nomenclature of Human... (099129)

    It is accepted that confusion regarding the description of genetic variants occurs when researchers do not use standard nomenclature. The Human Genome Organization Gene Nomenclature Committee contacted a panel of consultants, all working on the KAL1 gene, to propose an ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Helen A. King; André P. Gerber;
    Persistent Identifiers
    Publisher: Oxford Journals

    During the past decade, there has been a rapidly increased appreciation of the role of translation as a key regulatory node in gene expression. Thereby, the development of methods to infer the translatome, which refers to the entirety of mRNAs associated with ribosomes ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Graham B. Motion; Tiago M. M. M. Amaro; Natalja Kulagina; Edgar Huitema;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: EC | RETRAIN (310901)

    Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by inducing properly dos...

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  • publication . Article . 2017
    Open Access
    Authors:
    Chung-Chau Hon; Jay W. Shin; Piero Carninci; Michael J. T. Stubbington;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: WT , WT | Wellcome Trust Sanger Ins... (206194)

    Abstract The Human Cell Atlas is a large, international consortium that aims to identify and describe every cell type in the human body. The comprehensive cellular maps that arise from this ambitious effort have the potential to transform many aspects of fundamental bio...

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  • publication . Article . 2018
    Open Access Japanese
    Authors:
    Howard Ochman;

    The evolution of higher plants depended on the ability of cells to express hereditary information in many different ways and led to the development of specialized cell types, reflecting an elaborate system of control over gene expression in the individual component cell...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Lopes Novo, Clara; Rugg-Gunn, Peter;
    Publisher: Oxford University Press
    Project: WT | Epigenetic and Signal Tra... (093736), EC | EPIGENESYS (257082)

    Translating the vast amounts of genomic and epigenomic information accumulated on the linear genome into three-dimensional models of nuclear organization is a current major challenge. In response to this challenge, recent technological innovations based on chromosome co...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Dean C. Semmens; Maurice R. Elphick;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: UKRI | Neuropeptide function in ... (BB/M001644/1)

    Abstract Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals. Neuropeptide signalling has been investigated extensively in vertebrates and protostomian invertebrates, w...

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  • publication . Article . 2013
    Open Access
    Authors:
    Richard P. Halley-Stott; John B. Gurdon;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: WT , UKRI | Identification of chromos... (G1001690)

    Epigenetic memory represents a natural mechanism whereby the identity of a cell is maintained through successive cell cycles, allowing the specification and maintenance of differentiation during development and in adult cells. Cancer is a loss or reversal of the stable ...

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  • publication . Other literature type . Article . 2017
    Open Access English
    Authors:
    Mark Viney;
    Publisher: Oxford University Press
    Project: WT

    Nematodes are highly abundant animals, and many species have a parasitic lifestyle. Nematode parasites are important pathogens of humans and other animals, and there is considerable interest in understanding their molecular and genomic adaptations to nematode parasitism...

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  • publication . Article . 2014
    Open Access
    Authors:
    Sophia Ananiadou; Paul Thompson; Raheel Nawaz; John McNaught; Douglas B. Kell;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: UKRI | Supporting Evidence-based... (MR/L01078X/1), WT

    The assessment of genome function requires a mapping between genome-derived entities and biochemical reactions, and the biomedical literature represents a rich source of information about reactions between biological components. However, the increasingly rapid growth in...

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26 research outcomes, page 1 of 3