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28 research outcomes, page 1 of 3
  • publication . Article . 2018
    Open Access
    Authors:
    Howard Ochman;
    Publisher: Elsevier BV

    The evolution of higher plants depended on the ability of cells to express hereditary information in many different ways and led to the development of specialized cell types, reflecting an elaborate system of control over gene expression in the individual component cell...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Maarouf Baghdadi; Helena M Hinterding; Linda Partridge; Joris Deelen;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract Many of the leading causes of death in humans, such as cardiovascular disease, type 2 diabetes and Alzheimer’s disease are influenced by biological mechanisms that become dysregulated with increasing age. Hence, by targeting these ageing-related mechanisms, we ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Lopes Novo, Clara; Rugg-Gunn, Peter;
    Publisher: Oxford University Press (OUP)
    Project: EC | EPIGENESYS (257082), WT | Epigenetic and Signal Tra... (093736)

    Translating the vast amounts of genomic and epigenomic information accumulated on the linear genome into three-dimensional models of nuclear organization is a current major challenge. In response to this challenge, recent technological innovations based on chromosome co...

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  • publication . Article . 2017
    Open Access
    Authors:
    Dean C. Semmens; Maurice R. Elphick;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: UKRI | Neuropeptide function in ... (BB/M001644/1)

    Abstract Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals. Neuropeptide signalling has been investigated extensively in vertebrates and protostomian invertebrates, w...

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  • publication . Article . 2013
    Open Access
    Authors:
    Richard P. Halley-Stott; John B. Gurdon;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: WT , UKRI | Identification of chromos... (G1001690)

    Epigenetic memory represents a natural mechanism whereby the identity of a cell is maintained through successive cell cycles, allowing the specification and maintenance of differentiation during development and in adult cells. Cancer is a loss or reversal of the stable ...

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  • publication . Other literature type . Article . 2017
    Open Access English
    Authors:
    Mark Viney;
    Publisher: Oxford University Press
    Project: WT

    Nematodes are highly abundant animals, and many species have a parasitic lifestyle. Nematode parasites are important pathogens of humans and other animals, and there is considerable interest in understanding their molecular and genomic adaptations to nematode parasitism...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Sophia Ananiadou; Paul Thompson; Raheel Nawaz; John McNaught; Douglas B. Kell;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: UKRI | Supporting Evidence-based... (MR/L01078X/1), WT

    The assessment of genome function requires a mapping between genome-derived entities and biochemical reactions, and the biomedical literature represents a rich source of information about reactions between biological components. However, the increasingly rapid growth in...

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  • publication . Article . 2013
    Open Access
    Authors:
    Duncan Sproul; Richard R. Meehan;
    Publisher: Oxford University Press (OUP)
    Project: EC | MARCAR (115001)

    Carcinogenesis is thought to occur through a combination of mutational and epimutational events that disrupt key pathways regulating cellular growth and division. The DNA methylomes of cancer cells can exhibit two striking differences from normal cells; a global reducti...

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  • publication . Article . 2016
    Open Access
    Authors:
    Zeyad Abd Algfoor; Mohd Shahrizal Sunar; Afnizanfaizal Abdullah; Hoshang Kolivand;
    Persistent Identifiers

    Metabolic pathways have become increasingly available for variousmicroorganisms. Such pathways have spurred the development of a wide array of computational tools, in particular, mathematical pathfinding approaches. This article can facilitate the understanding of compu...

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  • publication . Article . 2012
    Open Access
    Authors:
    Megan C Neville; Stephen F. Goodwin;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Understanding how an organism exhibits specific behaviours remains a major and important biological question. Studying behaviour in a simple model organism like the fruit fly Drosophila melanogaster has the advantages of advanced molecular genetics approaches along with...

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28 research outcomes, page 1 of 3