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  • Open Access
    Authors: 
    Máté Varga; Kitti Csályi; Bertyák I; Dóra K. Menyhárd; Richard J. Poole; Kara L. Cerveny; Dorottya Kövesdi; Balázs L. Barátki; Rouse H; Vad Z; +6 more
    Publisher: Cold Spring Harbor Laboratory
    Project: UKRI | The zebrafish tectal stem... (BB/H008462/1), WT | Sexy glia: developmental ... (207483), WT | How is brain asymmetry es... (104682), WT | The specification of left... (095722), UKRI | Morphogenesis and growth ... (MR/L003775/1)

    AbstractEfficient and accurate DNA replication is particularly critical in stem and progenitor cells for successful proliferation and survival. The replisome, an amalgam of protein complexes, is responsible for binding potential origins of replication, unwinding the dou...

  • Open Access English
    Authors: 
    Catherine McCaig; Paris Ataliotis; Anan Shtaya; Ayan S Omar; A. Richard Green; Clive N Kind; Anthony C Pereira; Anikó Náray-Fejes-Tóth; Géza Fejes-Tóth; Rafael J. Yáñez-Muñoz; +2 more
    Publisher: SAGE Publications
    Country: United Kingdom
    Project: NIH | Mechanism of sgk action i... (5R01DK058898-03), UKRI | The Oxford Control Brain ... (G1000691)

    Nitrones (e.g. α-phenyl-N-tert-butyl nitrone; PBN) are cerebroprotective in experimental stroke. Free radical trapping is their proposed mechanism. As PBN has low radical trapping potency, we tested Sgk1 induction as another possible mechanism. PBN was injected (100 mg...

  • Publication . Article . 2015
    Open Access
    Authors: 
    Robin F. Irvine; Simon J. Bulley; Miranda S. C. Wilson; Adolfo Saiardi;
    Publisher: The Royal Society
    Project: UKRI | Dissecting inositol pyrop... (MC_U122680443)

    Indirect assays have claimed to quantify phytate (InsP 6 ) levels in human biofluids, but these have been based on the initial assumption that InsP 6 is there, an assumption that our more direct assays disprove. We have shown that InsP 6 does not and cannot (because of...

  • Open Access English
    Authors: 
    Laura Nuccio; Leander Schulz; Maureen Willis; F. L. Pratt; Martin Heeney; Natalie Stingelin; Christian Bernhard; Alan J. Drew;
    Project: UKRI | Investigation of intrinsi... (EP/G054568/1)

    Muon spin spectroscopy and in particular the avoided level crossing technique is introduced, with the aim of showing it as a very sensitive local probe for electron spin relaxation in organic semiconductors. Avoided level crossing data on TMS-pentacene at different temp...

  • Open Access
    Authors: 
    Zhixiong Hu; Andrew Glidle; Charles N. Ironside; Jonathan M. Cooper; Huabing Yin;
    Publisher: Royal Society of Chemistry (RSC)
    Country: United Kingdom
    Project: UKRI | Engineering a semi-biotic... (EP/H04986X/1), EC | BIO-PHONONICS (340117)

    We describe the development of an integrated lensed Arrayed Waveguide Grating (AWG) microspectrometer for localized multiplexing fluorescence measurements. The device, which has a footprint that is only 1 mm wide and 1 cm long, is capable of spectroscopic measurements o...

  • Publication . Article . 2013
    Open Access English
    Authors: 
    McElroy, Stuart P.; Nomura, Toshifumi; Torrie, Leah S.; Warbrick, Emma; Gartner, Ulrike; Wood, Gavin; McLean, W. H. Irwin;
    Publisher: Public Library of Science
    Project: WT | The establishment of a la... (090066), UKRI | In vivo model systems to ... (G0700314), WT | Human and mouse genetics ... (092530), UKRI | OPTIMISED DELIVERY OF THE... (G0801742)

    Author Summary Ten percent of all single-gene hereditary diseases are caused by nonsense mutations. These are alterations in the DNA sequence of a protein-coding gene that cause the ribosome to prematurely finish translating the gene transcript before a full-length, act...

  • Open Access English
    Authors: 
    Du Vivier, Alice D. C.; Selby, David; Sageman, Bradley B.; Jarvis, Ian; Groecke, Darren R.; Voigt, Silke;
    Publisher: Elsevier
    Country: United Kingdom
    Project: UKRI | Characterizing mantle inp... (NE/G009678/1), UKRI | Establishing causes of se... (NE/H020756/1), UKRI | Establishing causes of se... (NE/H021868/1)
  • Open Access English
    Authors: 
    Gnanapavan, S.; Ho, P.; Heywood, W.; Jackson, S.; Grant, D.; Rantell, K.; Keir, G.; Mills, K.; Steinman, L.; Giovannoni, G.;
    Publisher: Blackwell Publishing Ltd
    Country: United Kingdom
    Project: EC | MAPPER (261507), EC | CRESTA (287703), UKRI | A new approach to Science... (EP/I017909/1)

    Multiple sclerosis (MS) is a CNS disorder characterized by demyelination and neurodegeneration. Although hallmarks of recovery (remyelination and repair) have been documented in early MS, the regenerative capacity of the adult CNS per se remains uncertain with the wide ...

  • Open Access English
    Authors: 
    Laurel S. Morris; Benjaman To; Kwangyeol Baek; Yee-Chien Chang-Webb; Simon Mitchell; Daniela Strelchuk; Yevheniia Mikheenko; Wendy Phillips; Michael Zandi; Allison Jenaway; +2 more
    Publisher: Elsevier
    Project: WT | Dissecting compulsivity. (093705), UKRI | Self-control and motivati... (MR/P008747/1)

    Background Functional neurological disorder (FND) is an elusive disorder characterized by unexplained neurological symptoms alongside aberrant cognitive processing and negative affect, often associated with amygdala reactivity. Methods We examined the effect of negative...

  • Open Access English
    Authors: 
    Dudding, Tom; Haworth, Simon; Lind, Penelope A.; Sathirapongsasuti, J. Fah; Tung, Joyce Y.; Mitchell, Ruth; Colodro-Conde, Lucía; Medland, Sarah E.; Gordon, Scott; Elsworth, Benjamin; +5 more
    Publisher: Nature Publishing Group UK
    Project: NHMRC | Statistical Methods and A... (389892), NHMRC | Mapping Genes for typical... (389938), NHMRC | Genome-wide combined link... (389891), NHMRC | Association Screen of Hig... (442981), NIH | PERSISTENCE &CHANGE IN DR... (1R01AA007535-01A1), NIH | Genetic Epidemiology of P... (5R01MH066206-05), NHMRC | Investigating the role of... (552485), WT | Investigating the causal ... (201268), NHMRC | Identification of genetic... (389927), WT | Vitamin D and head and ne... (201237),...

    Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-w...