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315,782 research outcomes, page 1 of 31,579
  • publication . Article . Conference object . 2019
    Open Access
    Authors:
    Bino Varghese; Frank Chen; Darryl Hwang; Suzanne L. Palmer; Andre Luis de Castro Abreu; Osamu Ukimura; Monish Aron; Manju Aron; Inderbir S. Gill; Vinay Duddalwar; ...
    Publisher: ACM
    Project: NIH | Big Data U: Empowering Mo... (5U24ES026465-03), NIH | Boosting the Translationa... (5R01GM114434-02)

    Abstract Multiparametric magnetic resonance imaging (mpMRI) has become increasingly important for the clinical assessment of prostate cancer (PCa), but its interpretation is generally variable due to its relatively subjective nature. Radiomics and classification methods...

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  • publication . Article . 2010
    Open Access
    Authors:
    Barbieri, Christopher M.; Mack, Timothy R.; Robinson, Victoria L.; Miller, Matthew T.; Stock, Ann M.;
    Persistent Identifiers
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: NIH | Structure and Function of... (5R37GM047958-11)

    DNA-binding response regulators (RRs) of the OmpR/PhoB subfamily alternate between inactive and active conformational states, with the latter having enhanced DNA-binding affinity. Phosphorylation of an aspartate residue in the receiver domain, usually via phosphotransfe...

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  • publication . Article . 1998
    Open Access English
    Authors:
    Matthew Bogyo; Sunny Shin; John S. McMaster; Hidde L. Ploegh;
    Persistent Identifiers
    Publisher: Published by Elsevier Ltd.
    Project: NIH | CELL BIOLOGY--DEVELOPMENT... (5P30CA014051-17)

    Abstract Background: The proteasome is a multicatalytic protease complex responsible for most cytosolic protein breakdown. The complex has several distinct proteolytic activities that are defined by the preference of each for the carboxyterminal (P1) amino acid residue....

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  • publication . Article . 2012
    Open Access English
    Authors:
    Buganim, Yosef; Faddah, Dina A.; Cheng, Albert W.; Itskovich, Elena; Markoulaki, Styliani; Ganz, Kibibi; Klemm, Sandy L.; van Oudenaarden, Alexander; Jaenisch, Rudolf;
    Publisher: Elsevier Inc.
    Country: Netherlands
    Project: NIH | Stochastic gene expressio... (5DP1OD003936-02), NIH | In Vitro Reprogramming of... (5R37HD045022-13), NIH | Utilizing single cell app... (1F32GM099153-01A1), NIH | Organization and Infrastr... (5U54CA143874-04), NIH | GENOMIC IMPRINTING AND TH... (5R37CA084198-09)

    SummaryDuring cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming e...