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18,383 research outcomes, page 1 of 1,839
  • publication . Article . 2019
    Open Access English
    Authors:
    Minhas, Jatinder S.; Wang, Xia; Lavados, Pablo M.; Moullaali, Tom J.; Arima, Hisatomi; Billot, Laurent; Hackett, Maree L.; Olavarria, Veronica V.; Middleton, Sandy; Pontes-Neto, Octavio; ...
    Publisher: Nature Publishing Group
    Countries: Australia, United Kingdom
    Project: NHMRC | Improving the identificat... (1141328)

    The Head Positioning in Acute Stroke Trial (HeadPoST) is a pragmatic, international, cluster crossover randomized trial of 11,093 patients with acute stroke assigned to a lying-flat (0°) or sitting-up (head elevated ≥30°) position. This post hoc analysis aimed to determ...

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  • publication . Article . 2017
    Open Access
    Authors:
    Samuel J. Cutler; James D. Doecke; Ibtisam Ghazawi; Jinbo Yang; Lyn R. Griffiths; Kevin J. Spring; Stephen John Ralph; Albert S. Mellick;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NHMRC | Targeting bone marrow med... (1011114)

    Abstract Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are...

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  • publication . Article . 2016
    Open Access
    Authors:
    Florian Gerber; Thomas Gsponer;
    Persistent Identifiers
    Publisher: Foundation for Open Access Statistic
    Project: SNSF | Computing equipment (206021_144973), NHMRC | Equipment Grant (219240)

    The R package gsbDesign provides functions to evaluate the operating characteristics of Bayesian group sequential clinical trial designs. More specifically, we consider clinical trials with interim analyses, which compare a treatment with a control, and where the endpoi...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Dick, Jonathan; Gan, Poh-Yi; Kitching, A. Richard; Holdsworth, Stephen R.;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: NHMRC | The Therapeutic Role of C... (1046585), NHMRC | Therapeutic Blockade of C... (1075803)

    The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signalling by complement anaphylatoxin...

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  • publication . Article . Preprint . 2018
    Open Access
    Authors:
    Sila Genc; Robert E. Smith; Charles B Malpas; Vicki Anderson; Jan M. Nicholson; Daryl Efron; Emma Sciberras; Marc L. Seal; Timothy J. Silk;
    Publisher: Cold Spring Harbor Laboratory
    Project: NHMRC | Trajectories in brain str... (1065895), NHMRC | Improving outcomes for ch... (1110688)

    AbstractPurposeWhite matter fibre development in childhood involves dynamic changes to microstructural organisation driven by increasing axon diameter, density, and myelination. However, there is a lack of longitudinal studies that have quantified advanced diffusion met...

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  • publication . Artic