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As climate change increasingly affects the world, much is said about the rising amounts of aid required to support emergency response, long-term development to adapt, and peacebuilding to ensure that conflict does not undermine these efforts. Bringing these ideas together, some advocate for the addition of a separate climate change stream into the humanitarian, development, and peace/peacebuilding nexus (or triple nexus). Based on a critical literature review and synthesis, this article articulates and conceptualizes how climate change perspectives and actions should be integrated into the existing streams of the humanitarian, development, and peace/peacebuilding nexus, rather than being added as a separate stream. The analysis shows the risks of adding climate change as a stand-alone stream and advocates for developing long-term strategies that integrate climate change actions into humanitarian, development, and peacebuilding efforts to better serve all three.

A web platform will be provided, that makes policies from both NOURISHING and the physical activity databases easily and openly accessible.

This report contains the planned exploitation and dissemination activities

LORCENIS Workshop related to corrosion.

Increasing availability of multicore systems has led to greater focus on the design and implementation of languages for writing parallel programs. Such languages support various abstractions for parallelism, such as fork-join, async-finish, futures. While they may seem similar, these abstractions lead to different semantics, language design and implementation decisions, and can significantly impact the performance of end-user applications. In this paper, we consider the question of whether it would be possible to unify various paradigms of parallel computing. To this end, we propose a calculus, called dag calculus , that can encode fork-join, async-finish, and futures, and possibly others. We describe dag calculus and its semantics, establish translations from the aforementioned paradigms into dag calculus. These translations establish that dag calculus is sufficiently powerful for encoding programs written in prevailing paradigms of parallelism. We present concurrent algorithms and data structures for realizing dag calculus on multicore hardware and prove that the proposed techniques are consistent with the semantics. Finally, we present an implementation of the calculus and evaluate it empirically by comparing its performance to highly optimized code from prior work. The results show that the calculus is expressive and that it competes well with, and sometimes outperforms, the state of the art.

Effective biomarkers predictive of the response to treatments are key for precision medicine. This study identifies the staining pattern of the centromeric histone 3 variant, CENP-A, as a predictive biomarker of locoregional disease curability by chemoradiation therapy. We compared by imaging the subnuclear distribution of CENP-A in normal and tumoral tissues, and in a retrospective study in biopsies of 62 locally advanced head and neck squamous cell carcinoma (HNSCC) patients treated by chemoradiation therapy. We looked for predictive factors of locoregional disease control and patient’s survival, including CENP-A patterns, Ki67, HPV status and anisokaryosis. In different normal tissues, we reproducibly found a CENP-A subnuclear pattern characterized by CENP-A clusters both localized at the nuclear periphery and regularly spaced. In corresponding tumors, both features are lost. In locally advanced HNSCC, a specific CENP-A pattern identified in pretreatment biopsies predicts definitive locoregional disease control after chemoradiation treatment in 96% (24/25) of patients (OR = 17.6 CI 95% [2.6 362.8], p = 0.002), independently of anisokaryosis, Ki67 labeling or HPV status. The characteristics of the subnuclear pattern of CENP-A in cell nuclei revealed by immunohistochemistry could provide an easy to use a reliable marker of disease curability by chemoradiation therapy in locally advanced HNSCC patients.

ObjectiveAdiponectin is a protein abundantly secreted by the adipose tissue (AT). Plasma adiponectin levels are decreased in obese, insulin-resistant, and type 2 diabetic patients. Various multimeric complexes, i.e. high-, middle-, and low-molecular weight isoforms (HMW, MMW and LMW), are present in plasma. Here, we investigated the effect of weight reducing diet on the distribution of adiponectin isoforms in plasma and on their secretion in AT explants from obese subjects.DesignA total of 20 obese subjects (age 37.8±7.3 years, body mass index 33.9±5.0 kg/m2) underwent eight weeks of very low-calorie diet (VLCD). A needle biopsy of subcutaneous abdominal AT and blood samples were taken before and after dietary intervention. AT explants were incubated in culture medium for 4 h. ELISA assay and western blot analyses were used to identify adiponectin complexes in culture media and in plasma.ResultsThe distribution of adiponectin polymers in plasma was different from that secreted in human AT explants. Before VLCD, the relative amount of HMW isoform was 75.5±9.1% of total adiponectin in culture media and 52.2±11.2% in plasma. Despite the diet-induced weight loss and improvement of insulin sensitivity, VLCD neither induced change in total adiponectin level nor in the ratio of HMW to total adiponectin in plasma and in culture media of AT explants.ConclusionsThe profile of adiponectin polymeric isoforms secreted by AT explants into culture media differs from the plasma profile. A dietary intervention leading to weight loss and improvement of insulin sensitivity was not associated with modifications of AT secretion of total or HMW adiponectin.

Neutrinoless double beta decay (0nubb) is one of the most sensitive probes for physics beyond the Standard Model, providing unique information on the nature of neutrinos. In this paper we review the status and outlook for bolometric 0nubb decay searches. We summarize recent advances in background suppression demonstrated using bolometers with simultaneous readout of heat and light signals. We simulate several configurations of a future CUORE-like bolometer array which would utilize these improvements and present the sensitivity reach of a hypothetical next-generation bolometric 0nubb experiment. We demonstrate that a bolometric experiment with the isotope mass of about 1 ton is capable of reaching the sensitivity to the effective Majorana neutrino mass (|mee|) of order 10-20 meV, thus completely exploring the so-called inverted neutrino mass hierarchy region. We highlight the main challenges and identify priorities for an R&D program addressing them. 22 pages, 15 figures, submitted to EPJC

It is well known that there is no basis of the field for real numbers regarded as a vector space over any proper subfield that is closed under multiplication. Mabry has extended this result to bases of arbitrary proper field extensions. The aim of this short communication is to notice that the proof of the result concerning the reals may be adjusted to a larger class of algebras (including full matrix algebras); thereby we subsume Mabry's result. 3 pp., to appear in the American Mathematical Monthly