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description Publicationkeyboard_double_arrow_right Other literature type 2023American Association for Cancer Research (AACR) Authors: Nezar Al-hebshi; Christopher Fundakowski; Kumaraswamy Naidu Chitrala; Kathy Q. Cai; +6 AuthorsNezar Al-hebshi; Christopher Fundakowski; Kumaraswamy Naidu Chitrala; Kathy Q. Cai; Fadhl Alakwaa; Michael J. Slifker; Tsute Chen; Doaa E Elhadedy; Divyashri Baraniya; Vinay Jain;<p>Differentially abundant microbial enzyme classes (EC) and metabolic pathways (MaAsLin2).</p>
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021Elsevier BV Whitney Sutton; Joseph K. Canner; Lisa M. Rooper; Jason D. Prescott; Martha A. Zeiger; Aarti Mathur;BACKGROUND: Current data regarding the risk of malignancy in a large thyroid nodule with benign fine-needle aspiration biopsy(FNAB) is conflicting. We investigated the impact of patient age on the risk of malignancy in nodules≥4cm with benign cytology. METHODS: We performed a single-institution retrospective review of patients who underwent surgery from 07/2008-08/2019 for a cytologically benign thyroid nodule ≥4cm. The relationship between malignant histopathology and patient and ultrasound features was assessed with multivariable logistic regression. RESULTS: Of 474 nodules identified, 25(5.3%) were malignant on final pathology. In patients 4cm and high-risk ultrasound features were not associated with risk of malignancy(OR:1.0,95%CI:0.7-1.4,p=0.980, and OR:9.6,95%CI:0.9-107.8,p=0.066, respectively). CONCLUSIONS: Patients <55 years old are 3.7-fold more likely to have a falsely benign FNA biopsy in a nodule≥4cm.
The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 FranceInforma UK Limited NIH | Ivermectin for Malaria Co...NIH| Ivermectin for Malaria ControlAuthors: Haoues Alout; Brian D. Foy;Haoues Alout; Brian D. Foy;Introduction: Ivermectin has transformed the treatment of parasitic diseases and led to incommensurable benefits to humans and animals. Ivermectin is effective in treating several neglected infectious diseases and recently it has been shown to reduce malaria parasite transmission.Areas covered: Malaria control strategies could benefit from the addition of ivermectin to interrupt the transmission cycle if it is a long lasting formulation or repeatedly administered. In turn, this will help also to control neglected infectious diseases where the elimination goal has been slower to achieve. Despite the relevance of using ivermectin for integrated and sustained disease control, there are still essential questions that remain to be addressed about safety and practicality. The efficacy in various malaria ecologies and the interaction between control tools, either drugs or insecticides, are also important to assess.Expert commentary: Overlapping distribution of several infectious diseases reveals the benefit of integrating control programs against several infectious diseases into one strategy for cost effectiveness and to reach the elimination goals. The use of ivermectin to control malaria transmission will necessitate development and testing of long-lasting formulations or repeated treatments, and implementation of these treatments with other disease control tools may increase the chance of successful and sustained control.
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For further information contact us at helpdesk@openaire.eu23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019American Psychological Association (APA) Hilary F. Byrnes; Brenda A. Miller; Joel W. Grube; Beth Bourdeau; David B. Buller; Meme Wang-Schweig; W. Gill Woodall;This study examines effects of a randomized controlled trial for an online, family-based prevention program for older teens, Smart Choices 4 Teens, on alcohol use and related outcomes. Families (N = 411; teen age M = 16.4, SD = 0.5) were randomly assigned to the intervention or control condition in 2014-2015. Both intent to treat (ITT) and dosage models were conducted. ITT models: At the 6-month follow-up, teens in the experimental condition reported fewer friends who had been drunk, and parents in the experimental group reported more communication about social host laws. At the 12-month follow-up, parents in the experimental condition reported consuming fewer drinks than parents in the control group. Dosage models: At the 6-month follow-up, dosage was inversely related to teen drinking in the past 6 months or 30 days, frequency of teen drinking during the past 6 months and 30 days, drinks consumed by teens over the past 6 months, teen drunkenness and binge-drinking during the past 30 days, teen reported communication about safe drinking and positively related to parent and teen reported communication about social host laws. At 12 months, dosage was inversely related to teen alcohol use, frequency of teen drinking over the past 30 days, drinks consumed by teens over the past 6 months and 30 days, and teen drunkenness over the past 6 months. Results suggest that Smart Choices 4 Teens is beneficial for families. Dissemination and implementation strategies that motivate completion of program content will improve outcomes related to older teens' alcohol use. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012CMA Joule Inc. Authors: Wayne Kondro;Wayne Kondro;pmc: PMC3478372
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2020 Netherlands, United KingdomOxford University Press (OUP) EC | DMIDASEC| DMIDASJames M. M. Lane; Julio F. Navarro; Azadeh Fattahi; Kyle A. Oman; Jo Bovy;The Ophiuchus stream is a short arc-like stellar feature of uncertain origin located $\sim 5$ kpc North of the Galactic centre. New proper motions from the second $Gaia$ data release reconcile the direction of motion of stream members with the stream arc, resolving a puzzling mismatch reported in earlier work. We use N-body simulations to show that the stream is likely only on its second pericentric passage, and thus was formed recently. The simulations suggest that the entire disrupted progenitor is visible in the observed stream today, and that little further tidal debris lies beyond the ends of the stream. The luminosity, length, width, and velocity dispersion of the stream suggest a globular cluster (GC) progenitor substantially fainter and of lower surface brightness than estimated in previous work, and unlike any other known globulars in the Galaxy. This result suggests the existence of clusters that would extend the known GC population to fainter and more weakly bound systems than hitherto known. How such a weakly-bound cluster of old stars survived until it was disrupted so recently, however, remains a mystery. Integrating backwards in time, we find that the orbits of Sagittarius and Ophiuchus passed within $\sim 5$ kpc of each other about $\sim 100$ Myrs ago, an interaction that might help resolve this puzzle. Comment: 11 pages, 7 figures, submitted to MNRAS
Durham Research Onli... arrow_drop_down Durham Research Online; Monthly Notices of the Royal Astronomical SocietyOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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more_vert Durham Research Onli... arrow_drop_down Durham Research Online; Monthly Notices of the Royal Astronomical SocietyOther literature type . Article . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 1973Wiley Authors: Wesley G. Clark; Barbara A. Coldwell;Wesley G. Clark; Barbara A. Coldwell;1. The hypothermic effect on unanaesthetized cats of tetrodotoxin injected I.V. or into the lateral cerebral ventricle was examined.2. At an ambient temperature (T(a)) of 22 degrees C, tetrodotoxin given intraventricularly was over 400 times more potent in lowering body temperature (T(b)) than when given I.V. The magnitude of the hypothermia was dose-dependent for both routes. Decreases in T(b) as great as 6.8 degrees C were induced by infusions or multiple injections of tetrodotoxin into the ventricle.3. Tetrodotoxin also lowered T(b) at T(a) = 13, 30 or 35 degrees C. Tachypnoea, which lasted for longer durations and which became more intense the higher the T(a), accompanied development of hypothermia. Shivering was observed only during recovery from hypothermia at 13 degrees C.4. During the tetrodotoxin-induced hypothermia, animals were still able to regulate against environmental thermal stresses.5. EDTA disodium salt, leucocytic pyrogen and prostaglandin E(1) antagonized the hypothermic effect of tetrodotoxin when they were administered during recovery from tetrodotoxin.6. Activation of heat-loss mechanisms, and the absence of compensatory shivering during development of hypothermia after tetrodotoxin administration, plus lowering of T(b) by tetrodotoxin at T(a) above as well as below the thermoneutral temperature, indicate that lowering of the thermoregulatory set-point is the mechanism by which centrally or peripherally administered tetrodotoxin lowers T(b). Further evidence for set-point lowering after intraventricular administration of tetrodotoxin is provided by persistence of the ability to regulate against both heat and cold stresses during hypothermia. The possibility that the decrease in set-point could be due to the well known action of tetrodotoxin to block transient increases in membrane sodium ion conductance is discussed in terms of a recent hypothesis regarding ionic control of the thermoregulatory set-point.
The Journal of Physi... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu26 citations 26 popularity Average influence Top 10% impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2001 Finland, SwitzerlandAmerican Physical Society (APS) Authors: Ari Sihvola;Ari Sihvola;pmid: 11690172
This report presents the polarizability matrix of a tri-isotropic sphere. A tri-isotropic material exhibitscoupling between electric, magnetic, and in addition, a third kind of material response. Each of these threefields creates three different kind of polarizations. The paper derives the polarizability components of such asphere in vacuum and makes physical interpretations of the results for the copolarizabilities and cross polarizabilities. Peer reviewed
https://aaltodoc.aal... arrow_drop_down Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert https://aaltodoc.aal... arrow_drop_down Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016MDPI AG Deguan Li; Zhenyuan Tian; Weisheng Tang; Junling Zhang; Lu Lu; Zhaojin Sun; Zewei Zhou; Feiyue Fan;Antioxidants are prospective radioprotectors because of their ability to scavenge radiation-induced reactive oxygen species (ROS). The hematopoietic system is widely studied in radiation research because of its high radiosensitivity. In the present study, we describe the beneficial effects of 5-methoxytryptamine-α-lipoic acid (MLA), which was synthesized from melatonin and α-lipoic acid, against radiation-induced hematopoietic injury. MLA administration significantly enhanced the survival rate of mice after 7.2 Gy total body irradiation. The results showed that MLA not only markedly increased the numbers and clonogenic potential of hematopoietic cells but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, MLA decreased the levels of ROS in hematopoietic cells by inhibiting NOX4 expression. These data demonstrate that MLA prevents radiation-induced hematopoietic syndrome by increasing the number and function of and by inhibiting DNA damage and ROS production in hematopoietic cells. These data suggest MLA is beneficial for the protection of radiation injuries.
International Journa... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu32 citations 32 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2013Zenodo Authors: Galea, Horia R.;Galea, Horia R.;Hincksella formosa (Fewkes, 1881) (Fig. 6 U���Z) Sertularella formosa Fewkes, 1881: 130.― Nutting, 1895: figs 2, 2A; 1904: 104, pl. 27 figs 2���4.― Fraser, 1944: 260, pl. 55 fig. 246.― Vervoort, 1959: 264, figs 27 C, 29. Sertularia integritheca Allman, 1888: 60, pl. 29 figs 2, 2A.― Nutting, 1895: 88.― Versluys, 1899: 37. Sertularella hartlaubi Nutting, 1904: 104, pl. 27 fig. 5.―Galea, 2009: 65, fig. 2 J���L. Hincksella formosa ― Calder & Kirkendale, 2005: 484. Material examined. Stn. 8, 25.i.2012, 12��� 15 m, M052: numerous colonies and fragments 2.5���10 cm high, some with gonothecae (MHNG-INVE- 82890); 27.i.2012, 9��� 15 m, M061: two fertile colonies 4.0 and 7.5 cm, respectively (MHNG-INVE- 82938). Stn. 14, 20.ii.2012, 10��� 13 m, M 231: numerous erect stems, 2���12 cm high, some bearing gonothecae (MHNG-INVE- 82939). Remarks. For a redescription of the trophosome, refer to Vervoort (1959). The gonotheca was described by Nutting (1904) and his account is generally accurate. However, the "four flapped membranous operculum" observed by him is not an anatomical structure, but rather the result of the distal perisarc sheet of the gonotheca (Fig. 6 Y) rupturing, thus allowing the release of the gametes. The gonotheca is 2050���2195 ��m long and 1035���1120 ��m wide in middle, and is provided with 2���4 distal, blunt spines. One of its lateral sides is always concave (Fig. 6 V, X), though not necessarily that adnate to the internode. Cnidome (not previously reported): 1) slender microbasic heteronemes, (6.9���7.4)��(2.6���2.9) ��m; 2) slightly larger microbasic heteronemes, (7.7���8.2)�� 3.5 ��m; 3) huge macrobasic mastigophores, (26.6���29.8)��(6.9���7.7) ��m. Geographical distribution. Widely distributed in the tropical eastern and western Atlantic, but also occurring in the tropical eastern Pacific: Brazil (Allman 1888, as Sertularia integritheca), Bahamas (Nutting 1895, as S. integritheca), Cuba (Nutting 1904), Peru (Nutting 1904, as Sertularella hartlaubi), Ghana (Vervoort 1959, as Sertularella formosa). In the Caribbean, it was reported from Grenada and Martinique (Fewkes 1881), Testigos (Versluys 1899, as S. integritheca), from an offshore locality between Jamaica and Haiti (Nutting 1904, as S. hartlaubi), and from Panama (Calder & Kirkendale 2005). {"references": ["Fewkes, J. W. (1881) Report on the Acalephae. In: Reports on the results of dredging, under the supervision of Alexander Agassiz, in the Caribbean Sea, in 1878, 1879, and along the Atlantic coast of the United States, during the summer of 1880, by the U. S. Coast Survey Steamer Blake. Bulletin of the Museum of Comparative Zoology, at Harvard College, 8 (7), 127 - 140.", "Nutting, C. C. (1895) Narrative of Bahama Expedition. Bulletin from the Laboratories of Natural History, State University of Iowa, 3 (1), 1 - 251.", "Fraser, C. M. (1944) Hydroids of the Atlantic coast of North America. The University of Toronto Press, Toronto, 451 pp.", "Vervoort, W. (1959) The Hydroida of the tropical west coast of Africa. Atlantide Report, 5, 211 - 332.", "Allman, G. J. (1888) Report on the Hydroida dredged by H. M. S. Challenger during the years 1873 - 76. Part II. - The Tubularinae, Corymorphinae, Campanularinae, Sertularinae and Thalamophora. Report on the Scientific Results of the Voyage of H. M. S. Challenger during the year 1873 - 76, Zoology, 23 (70), 1 - 90.", "Versluys, J. J. (1899) Hydraires calyptoblastes recueillis dans la mer des Antilles, pendant l'une des croisieres accomplies par le comte R. de Dalmas sur son yacht \" Chazalie \". Memoires de la Societe Zoologique de France, 12, 29 - 58.", "Nutting, C. C. (1904) American hydroids. Part II. The Sertularidae. Special Bulletin of the United States National Museum, 4 (2), 1 - 325.", "Calder, D. R. & Kirkendale, L. (2005) Hydroids (Cnidaria, Hydrozoa) from shallow-water environments along the Caribbean coast of Panama. Caribbean Journal of Science, 41 (3), 476 - 491."]} Published as part of Galea, Horia R., 2013, New additions to the shallow-water hydroids (Cnidaria: Hydrozoa) of the French Lesser Antilles: Martinique, pp. 1-50 in Zootaxa 3686 (1) on pages 25-26, DOI: 10.11646/zootaxa.3686.1.1, http://zenodo.org/record/284148
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description Publicationkeyboard_double_arrow_right Other literature type 2023American Association for Cancer Research (AACR) Authors: Nezar Al-hebshi; Christopher Fundakowski; Kumaraswamy Naidu Chitrala; Kathy Q. Cai; +6 AuthorsNezar Al-hebshi; Christopher Fundakowski; Kumaraswamy Naidu Chitrala; Kathy Q. Cai; Fadhl Alakwaa; Michael J. Slifker; Tsute Chen; Doaa E Elhadedy; Divyashri Baraniya; Vinay Jain;<p>Differentially abundant microbial enzyme classes (EC) and metabolic pathways (MaAsLin2).</p>
https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1158/2767-9764.22651730&type=result"></script>'); --> </script>
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more_vert https://doi.org/10.1... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021Elsevier BV Whitney Sutton; Joseph K. Canner; Lisa M. Rooper; Jason D. Prescott; Martha A. Zeiger; Aarti Mathur;BACKGROUND: Current data regarding the risk of malignancy in a large thyroid nodule with benign fine-needle aspiration biopsy(FNAB) is conflicting. We investigated the impact of patient age on the risk of malignancy in nodules≥4cm with benign cytology. METHODS: We performed a single-institution retrospective review of patients who underwent surgery from 07/2008-08/2019 for a cytologically benign thyroid nodule ≥4cm. The relationship between malignant histopathology and patient and ultrasound features was assessed with multivariable logistic regression. RESULTS: Of 474 nodules identified, 25(5.3%) were malignant on final pathology. In patients 4cm and high-risk ultrasound features were not associated with risk of malignancy(OR:1.0,95%CI:0.7-1.4,p=0.980, and OR:9.6,95%CI:0.9-107.8,p=0.066, respectively). CONCLUSIONS: Patients <55 years old are 3.7-fold more likely to have a falsely benign FNA biopsy in a nodule≥4cm.
The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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more_vert The American Journal... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 FranceInforma UK Limited NIH | Ivermectin for Malaria Co...NIH| Ivermectin for Malaria ControlAuthors: Haoues Alout; Brian D. Foy;Haoues Alout; Brian D. Foy;Introduction: Ivermectin has transformed the treatment of parasitic diseases and led to incommensurable benefits to humans and animals. Ivermectin is effective in treating several neglected infectious diseases and recently it has been shown to reduce malaria parasite transmission.Areas covered: Malaria control strategies could benefit from the addition of ivermectin to interrupt the transmission cycle if it is a long lasting formulation or repeatedly administered. In turn, this will help also to control neglected infectious diseases where the elimination goal has been slower to achieve. Despite the relevance of using ivermectin for integrated and sustained disease control, there are still essential questions that remain to be addressed about safety and practicality. The efficacy in various malaria ecologies and the interaction between control tools, either drugs or insecticides, are also important to assess.Expert commentary: Overlapping distribution of several infectious diseases reveals the benefit of integrating control programs against several infectious diseases into one strategy for cost effectiveness and to reach the elimination goals. The use of ivermectin to control malaria transmission will necessitate development and testing of long-lasting formulations or repeated treatments, and implementation of these treatments with other disease control tools may increase the chance of successful and sustained control.