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A case with the progressive gangrenous rhinitis was reported.He was a 34-year-old male who unfortunately expired following intestinal bleeding with peritonitis-like symptoms.Improvement in the general condition was the initial step by the administration of medicines and then surgey, radi- ation therapy and steroid hormone treatment were used and a somewhat clinically effective improve- ment in the symptoms was obtained but in using the radiation therapy and the steroid hormones we must take note of the nature of the "iatrogenic disease".We reported the 7 cases with the pro- gressive gangrenous rhinitis seen from 1955 to 1961(5 cases had already died and 2 cases are yet alive) who consulted the OtorhinolaryngologicaIDept.of Osaka University Hospital.According to their clinical findings and examinations, this disease should be suspected when ulceration and granulation, in nasal cavity or accessory nasal cavity, remittent fever(resistant to antibiotics), continual accerelation. of sedimentation rate and no swelling of lymphno des, no specific findings in bacteriology and serology are found.And in such cases it was much better- to improve the general condition and then take- surgical and radiation means immediately.It was- concluded that Survival or follow-up result of this- disease shonld be studied further.

Background: Hypertonic saline (HS) and mannitol are hyperosmolar agents that are usually used to reduce intracranial pressure (ICP) and provide a satisfactory brain relaxation. The aim of the study was to perform a systematic review and meta-analysis to compare the efficacy of HS and mannitol on brain relaxation intraoperatively in patient undergoing craniotomies for supra-tentorial brain tumors. Methods: We included systematic review and meta-analysis of randomized control trials. We included randomized control trials that compared equiosmolar HS and mannitol in supratentorial tumors craniotomies and reported at least one of the following outcomes: degree of brain relaxation, ICP, central venous pressure, mean arterial pressure, perioperative fluid input, urine output, Na+ levels, and K+ levels. We searched Medline, Cochrane Central Register of Controlled Trials, and Embase using MESH terms and keywords. The bibliographic references of included studies and trial registries were also searched. Results: Seven articles were included. The degree brain of relaxation was comparable across the two groups with slight tendency toward HS (RR = 1.13, 95% CI 0.99–1.29; P = 0.08). Mannitol was associated with significantly higher urine output (standardized mean difference [SMD] = −1.33, 95% CI −1.56–−1.10; P < 0.001). Na+ levels were higher in HS group (SMD = 1.47, 95% CI 0.86–2.09; P < 0.001). Mannitol was associated with non-significant decrease in CVP and increase fluid input (SMD = 0.42, 95% CI 0.00–0.85 and SMD = −0.18, 95% CI −0.37–0.02, respectively). Conclusion: Both HS and mannitol are associated with satisfactory brain relaxation with a non-statistically significant tendency for HS to achieve better relaxation scores with mannitol resulting in higher urine output while HS with higher Na+ levels.

Sexual desire discrepancy has been associated with sexual and relationship dissatisfaction. Nonetheless, little is known regarding the role of desire discrepancy in gay men, as main research has been systematically conducted with heterosexual couples. Also, only one study has focused on problematic sexual desire discrepancies and sexual satisfaction with lesbian women. This study sought to understand if perceived sexual desire discrepancy influences sexual and relationship satisfaction in men, and to explore differences according to sexual orientation. A total of 346 men (245 heterosexual and 101 gay) completed an online survey and answered sociodemographic questions, a specific question about sexual desire discrepancy, and completed the Global Measure of Sexual Satisfaction and the Global Measure of Relationship Satisfaction. The main findings showed differences in sexual and relationship satisfaction according to sexual desire discrepancy groups, with men who experienced no desire discrepancy being more satisfied within their relationship and sex life compared to men who experienced both problematic and nonproblematic sexual desire discrepancy. Additionally, men who experienced nonproblematic sexual desire discrepancy reported being more sexually and relationship satisfied than men who experienced problematic sexual desire discrepancy. No sexual orientation differences were found. Overall, current findings emphasize the role of (non)problematic desire discrepancy in sexual and relationship satisfaction among heterosexual and gay men. - (undefined)

Members of the Notch family are involved in the development of breast cancer in animal models and in humans. In young transgenic mice, expressing intracellular activated Notch1 (N1(IC)) in mammary cells, we found that CD24(+) CD29(high) progenitor cells had enhanced survival, and were expanded through a cyclin D1-dependent pathway. This expansion positively correlated with the later cyclin D1-dependent formation of basal-like ductal tumors. This expanded population exhibited abnormal differentiation skewed toward the basal cells, showed signs of pre-malignancy (low PTEN/p53 and high c-myc) and contained stem cells with impaired self-renewal in vivo, and more numerous multipotent, ductal-restricted progenitors. Our data suggest that N1(IC) can favor transformation of progenitor cells early in life through a cyclin D1-dependent pathway.

V532 Oph has been found to be a member of the rare, hydrogen-deficient R Coronae Borealis (RCB) stars from new photometric and spectroscopic data reported in this paper. The lightcurve of V532 Oph shows the sudden, deep, irregularly spaced declines characteristic of RCB stars. Its optical spectrum is typical of a warm (T(eff)~7000 K) RCB star, showing weak or absent hydrogen lines, the C2 Swan bands, and no evidence for 13C. In addition, the star shows small pulsations typical of an RCB star and an infrared excess due to circum- stellar dust. It also appears to be significantly reddened by foreground dust. The distance to V532 Oph is estimated to be 5.5-8.7 kpc. These new data show that this star was misclassified as an eclipsing binary in the General Catalog of Variable Stars. The new data presented here for V532 Oph reveal the power of high-quality, high-cadence all-sky photometric surveys, such as ASAS-3, to identify new RCB candidates on the basis of lightcurve data alone, now that they have been collecting data for durations sufficiently long to reveal multiple declines. Despite their small numbers, RCB stars may be of great importance in understanding the late stages of stellar evolution. In particular, their measured isotopic abundances imply that many, if not most, RCB stars are produced by WD mergers, which may be the low-mass counterparts of the more massive mergers thought to produce type Ia supernovae. Therefore, establishing the population of RCB stars in the Galaxy will help constrain the frequency of these WD mergers. Comment: 11 pages, 4 figures, PASP in press

We investigated the processing of violations of the verb position in Dutch, in a group of healthy subjects, by measuring event-related potentials (ERPs) through electroencephalography (EEG). In Dutch, the base position of the verb is clause final, but in matrix clauses, the finite verb is in second position, a construction known as Verb Second. In embedded clauses, the finite verb remains in its clause-final base position. The results show that ungrammatical placement of finite verbs in second position in embedded clauses yields a P600 response, which suggests that the parser treats this type of violation as a clear syntactic anomaly. This is in contrast to accounts by which a general preference for subject-verb-object word order in languages like Dutch is reflected by an absence of P600 effects in response to violations of Verb Second.

It has been reported that sustained post-exercise vasodilation may be linked to exercise-induced angiogenesis. The present study aimed to evaluate whether mild hypobaric hypoxia enhances the post-exercise reduction in systemic vascular resistance in young male runners. Seven male intercollegiate runners (aged 19–21 years) performed maximal incremental treadmill running under conditions of hypobaric hypoxia (corresponding to 2,200 m above sea level, hereinafter referred to as HH) and normobaric normoxia (corresponding to sea level, hereinafter referred to as NN). A third exercise test was performed under NN conditions, consisting of submaximal exercise with the same absolute exercise volume as was achieved during HH (submaximal exercise under NN conditions, hereinafter referred to as NNsubmax). Blood pressure and cardiac output (CO) were measured before and at 15, 30, and 60 (p60) minutes after exercise. Compared with NN, exercise time was shorter in HH and NNsubmax conditions (p < 0.05). Systolic blood pressure and mean blood pressure (MBP) were lower after exercise in HH conditions (p < 0.05). No condition-related differences were found in CO. Total peripheral resistance (TPR, defined as the ratio of MBP to CO) was significantly lower after exercise compared to baseline for all conditions (p < 0.05). However, the decrease in TPR was maintained longer after exercise in HH compared with NN and NNsubmax conditions (p < 0.05). At p60, TPR was lower than baseline for HH conditions (p < 0.05), whereas after exercise in NN, and NNsubmax conditions, TPR recovered to baseline by p60. Decreases in systemic vascular resistance after exercise were maintained longer under mild HH conditions compared with NN despite the lower exercise volume of the former.