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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Schmitt, Andrea; Otto, Sylvia; Jatzko, Alexander; Ruf, Matthias; +6 Authors

    OBJECTIVES: In first-episode schizophrenia patients, functional magnetic resonance imaging (fMRI) has shown prefronto-parietal dysfunction during acoustic and visual stimulation. The aim of this study was to investigate the prefronto-parietal network in elderly schizophrenia patients using the same paradigm. Additionally, we hypothesized favourable effects on brain activation by the atypical antipsychotic clozapine compared to typical neuroleptics. METHODS: We investigated 18 elderly, chronic schizophrenia patients and 21 elderly healthy controls. Nine schizophrenia patients had been medicated with clozapine and 9 had been receiving typical neuroleptics over decades. In addition to assessments with psychopathological and neuropsychological rating scales we used an acoustic and visual stimulation paradigm in a 1.5 Tesla MRI scanner to investigate BOLD-response in different brain areas. RESULTS: Compared to healthy controls schizophrenia patients showed decreased brain activation in the prefrontal and parietal cortex as well as medial anterior cingulate gyrus compared to healthy controls. In these regions, patients medicated with clozapine showed increased BOLD-response compared to patients treated with typical neuroleptics. DISCUSSION: Our study confirmed prefronto-parietal network disturbances in elderly schizophrenia patients thus pointing to the preservation of brain activation deficits and the influence of neurodevelopmental disturbances in chronic schizophrenia until old-age. CONCLUSION: The atypical antipsychotic clozapine seems to facilitate brain activation even in elderly, chronic schizophrenia patients. OBJETIVOS: Em pacientes com primeiro episódio de esquizofrenia, estudos com ressonância magnética funcional (RMf) têm demonstrado disfunção pré-frontoparietal durante estimulação acústica e visual. O objetivo do presente estudo foi investigar a rede pré-frontoparietal em pacientes idosos com esquizofrenia utilizando o mesmo paradigma. Adicionalmente, foram presumidos efeitos favoráveis na ativação cerebral pelo antipsicótico atípico clozapina em comparação a neurolépticos típicos. MÉTODOS: Foram investigados 18 pacientes com esquizofrenia crônica e 21 controles saudáveis idosos. Nove pacientes com esquizofrenia haviam sido medicados com clozapina e nove haviam recebido neurolépticos típicos por décadas. Concomitantemente às avaliações com escalas psicopatológicas e neuropsicológicas foi utilizado um paradigma de estimulação auditiva e visual em um aparelho de ressonância magnética de 1,5 Tesla para investigar a resposta BOLD em diferentes áreas cerebrais. RESULTADOS: Comparados a controles saudáveis, os pacientes com esquizofrenia apresentaram diminuição na ativação cerebral nos córtices pré-frontal e parietal, assim como no giro do cíngulo anterior medial. Nessas regiões, os pacientes medicados com clozapina apresentaram resposta BOLD aumentada em comparação aos pacientes tratados com neurolépticos típicos. DISCUSSÃO: O presente estudo confirmou a presença de distúrbios na rede pré-frontoparietal em pacientes idosos com esquizofrenia, apontando assim para a preservação de déficits de ativação cerebrais e a influência de distúrbios do desenvolvimento neural em esquizofrenia crônica até a velhice. CONCLUSÃO: O antipsicótico atípico clozapina parece facilitar a ativação de áreas cerebrais mesmo em pacientes idosos com esquizofrenia crônica.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Solleiro-Rebolledo, Elizabeth; Sedov, Sergey; Sycheva, Svetlana; Sánchez Pérez, Serafín; +2 Authors

    Dada la importancia que revisten los suelos en los procesos que ocurren en la zona crítica (zona de interacción entre agua, suelo, aire, organismos), en este trabajo presentamos la distribución temporal y espacial de una secuencia de paleosuelos arcillosos con carbonatos secundarios (capas de caliches y carbonatos diseminados) en el sector nororiental de la Cuenca de México, particularmente en el valle de Teotihuacán. El propósito de este trabajo consiste en reconstruir la distribución temporal y espacial de la cubierta de suelos del pasado para entender su relación con la estructura actual de suelos y sedimentos en este sector semiárido de la cuenca de México. Con esta información, determinar la participación de estos materiales en la Zona Crítica (ZC). Para ello, se ha llevado a cabo un transecto de dirección norte-sur, que inicia en las elevaciones del Cerro Gordo, cruza el valle de Teotihuacán y termina en la Sierra Patlachique, describiendo perfiles de suelo en diferentes posiciones geomorfológicas. El marco cronológico se ha establecido con base en fechamientos de radiocarbono realizados en las capas de caliches. De acuerdo a la cronología, al tipo y grado de pedogénesis, y a los procesos de sedimentación, se han reconocido cuatro unidades. La primera unidad, denominada Paleosuelos del Pleistoceno, fase I (50000 – 20000 años AP), está compuesta de paleosuelos arcillosos, los cuales son Luvisoles crómicos y estágnicos, dependiendo de su posición en el paisaje. Estos paleosuelos muestran tanto carbonatos secundarios diseminados y en fracturas, como capas de caliches. En la segunda unidad, Paleosuelos del Pleistoceno, fase II (20000 –10000 años AP), dominan los sedimentos sobre los suelos; únicamente en el fondo del Valle, se han encontrado Gleysoles cortados por canales aluviales. La unidad, Paleosuelos del Holoceno, fase I (10000 a 1000 años AP) se caracteriza por presentar suelos poligenéticos (Vertisoles), fuertemente modificados por los procesos antrópicos, durante las diversas fases de ocupación pre-hispánica. La última unidad, Suelos del Holoceno, fase II, abarca el último milenio, en donde se destacan procesos de erosión e inestabilidad del paisaje. La tendencia principal en la distribución espacial de los paleosuelos es la siguiente: las unidades antiguas (Luvisoles, capas de caliches y Vertisoles) están sepultadas profundamente en el fondo del valle. Sin embargo, en los taludes y elevaciones montañosas, pueden aparecer cerca o directamente sobre la superficie, siendo incorporados en el manto de suelos actual. Las interrelaciones entre los diferentes paleosuelos a lo largo del transecto estudiado, junto con las observaciones micromorfológicas, apoyan la hipótesis de una relación evolutiva entre los Luvisoles pleistocénicos y los Vertisoles del Holoceno. Consideramos que estas diferentes unidades repercuten en los procesos hidrológicos en el valle y que las capas de caliche formadas en los ambientes pleistocénicos pueden afectar la geoquímica del agua subterránea así como sus firmas isotópicas. As soils are important elements for the processes involved in the critical zone (the zone of interaction between water, soil, air, and organisms), in this work we present the temporal and spatial distribution of a clayey-paleosol sequence with secondary carbonates (layers of caliche and disseminated carbonates) in the northeast sector of the Mexico Basin, particularly in the Teotihuacan Valley. The goal of this paper is the temporal and spatial reconstruction of the past soil cover to understand its relationship with the present day soils and sediments in this semiarid sector of the Mexico Basin. With this information the involvement of these materials in the critical zone could be determined. To comply with these objectives, a north-south transect was carried out, starting in the Cerro Gordo, crossing the Teotihuacan valley and ending in the Sierra Patlachique, describing soil profiles located in different geomorphological positions. The chronological framework has been established with radiocarbon dates of the caliche layers. According to this chronology, the type and degree of pedogenesis, as well as the sedimentation processes, four units have been recognized. The first unit is named the Pleistocene Paleosols, phase I (50000 – 20000 years BP), and is composed of clayey paleosols, chromic and stagnic Luvisols, depending on their position in the landscape. These paleosols contain pedogenic carbonates, disseminated and in fractures, and caliche layers. In the second unit, the Pleistocene Paleosols, phase II (20000 –10000 years BP), sediments predominate over soils; only in the valley floor some Gleysols are found to be cut by alluvial channels. The unit, Paleosols of the Holocene Paleosols unit, phase I (10000 to 1000 years BP), is characterized by polygenetic soils (Vertisols) strongly modified by anthropic processes during distinct phases of pre-hispanic occupation. The last unit, the Holocene Soils, phase II, covers the last millennium when erosional processes and unstable landscape dominate. The paleosols (Luvisols, caliche layers, and Vertisols) are deeply buried at the bottom of the valley. However, on the slopes and hilltop positions, they can appear close to or directly on the surface, being incorporated in the present day soil mantle. Spatial interrelations of different paleosols along the studied transect together with micromorphological observations support the hypothesis of an evolutionary link between the Pleistocene Luvisols and the Holocene Vertisols. We propose that these different units are involved in the hydrological processes in the valley and that the caliche layers, formed in the Pleistocene environments, can affect the geochemistry of the groundwater as well as its isotopic signatures.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ambos, Kai;

    peerReviewed

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    Authors: Ambos, Kai;

    peerReviewed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Göttingen Research O...arrow_drop_down
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    Authors: Poblete, Hernán; Roffael, Edmone; Miertzsch, Helmut;

    Se determinó la disminución de la bioluminiscencia de bacterias como indicador de la actividad biológica de extractos de corteza. Se analizaron cuatro cortezas nativas chilenas. La reducción de la bioluminiscencia fue diferente dependiendo de la especie de corteza. El aumento del tiempo de un tratamiento térmico de la corteza (24, 48, 72 y 144 horas con 103ºC) produjo una reducción de la actividad biológica de los extractos. El estudio indica que los terpenos podrían ser responsables del efecto señalado Bioluminescence decrease of bacteria as a biological activity indicator for bark water extracts was determinate. Four Chilean barks were tested. A different reduction on bioluminescence depending on bark species was observed. Increasing time of thermal treatment of bark (24, 48, 72 and 144 hours with 103ºC) produced a reduction of the biological activity of extracts. The study indicates that the terpenes could be responsible for the described effect

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    Fraunhofer-ePrints
    Article . 2007
    Data sources: Fraunhofer-ePrints
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      Fraunhofer-ePrints
      Article . 2007
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    Authors: García García, M.;

    Con el propósito de ampliar nuestro conocimiento acerca de la competencia conversacional en español como lengua extranjera y su enseñanza, este artículo analiza las características interactivas de la interlengua de once estudiantes de español participantes en nueve conversaciones. Los resultados del estudio ponen de manifiesto la falta de recursos de los hablantes no nativos a la hora de señalizar los procesos interactivos, así como una ausencia de iniciativa en el manejo de la interacción, lo que demuestra la necesidad de un enfoque explícito en la enseñanza de la conversación y asimismo la conveniencia de continuar la investigación en este campo. With the objective being to provide insights on the acquisition of second language conversational competence and its teaching, this paper analyzes the interactional features of the speech of eleven non-native speakers of Spanish in nine audiotaped conversations. Results of the study show learners' lack of resources to signal interactive processes as well as an absence of initiative in the management of interaction, which demonstrate the need for an explicit approach to conversation teaching and continued research in this field.

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6 Research products
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Schmitt, Andrea; Otto, Sylvia; Jatzko, Alexander; Ruf, Matthias; +6 Authors

    OBJECTIVES: In first-episode schizophrenia patients, functional magnetic resonance imaging (fMRI) has shown prefronto-parietal dysfunction during acoustic and visual stimulation. The aim of this study was to investigate the prefronto-parietal network in elderly schizophrenia patients using the same paradigm. Additionally, we hypothesized favourable effects on brain activation by the atypical antipsychotic clozapine compared to typical neuroleptics. METHODS: We investigated 18 elderly, chronic schizophrenia patients and 21 elderly healthy controls. Nine schizophrenia patients had been medicated with clozapine and 9 had been receiving typical neuroleptics over decades. In addition to assessments with psychopathological and neuropsychological rating scales we used an acoustic and visual stimulation paradigm in a 1.5 Tesla MRI scanner to investigate BOLD-response in different brain areas. RESULTS: Compared to healthy controls schizophrenia patients showed decreased brain activation in the prefrontal and parietal cortex as well as medial anterior cingulate gyrus compared to healthy controls. In these regions, patients medicated with clozapine showed increased BOLD-response compared to patients treated with typical neuroleptics. DISCUSSION: Our study confirmed prefronto-parietal network disturbances in elderly schizophrenia patients thus pointing to the preservation of brain activation deficits and the influence of neurodevelopmental disturbances in chronic schizophrenia until old-age. CONCLUSION: The atypical antipsychotic clozapine seems to facilitate brain activation even in elderly, chronic schizophrenia patients. OBJETIVOS: Em pacientes com primeiro episódio de esquizofrenia, estudos com ressonância magnética funcional (RMf) têm demonstrado disfunção pré-frontoparietal durante estimulação acústica e visual. O objetivo do presente estudo foi investigar a rede pré-frontoparietal em pacientes idosos com esquizofrenia utilizando o mesmo paradigma. Adicionalmente, foram presumidos efeitos favoráveis na ativação cerebral pelo antipsicótico atípico clozapina em comparação a neurolépticos típicos. MÉTODOS: Foram investigados 18 pacientes com esquizofrenia crônica e 21 controles saudáveis idosos. Nove pacientes com esquizofrenia haviam sido medicados com clozapina e nove haviam recebido neurolépticos típicos por décadas. Concomitantemente às avaliações com escalas psicopatológicas e neuropsicológicas foi utilizado um paradigma de estimulação auditiva e visual em um aparelho de ressonância magnética de 1,5 Tesla para investigar a resposta BOLD em diferentes áreas cerebrais. RESULTADOS: Comparados a controles saudáveis, os pacientes com esquizofrenia apresentaram diminuição na ativação cerebral nos córtices pré-frontal e parietal, assim como no giro do cíngulo anterior medial. Nessas regiões, os pacientes medicados com clozapina apresentaram resposta BOLD aumentada em comparação aos pacientes tratados com neurolépticos típicos. DISCUSSÃO: O presente estudo confirmou a presença de distúrbios na rede pré-frontoparietal em pacientes idosos com esquizofrenia, apontando assim para a preservação de déficits de ativação cerebrais e a influência de distúrbios do desenvolvimento neural em esquizofrenia crônica até a velhice. CONCLUSÃO: O antipsicótico atípico clozapina parece facilitar a ativação de áreas cerebrais mesmo em pacientes idosos com esquizofrenia crônica.

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    Authors: Solleiro-Rebolledo, Elizabeth; Sedov, Sergey; Sycheva, Svetlana; Sánchez Pérez, Serafín; +2 Authors

    Dada la importancia que revisten los suelos en los procesos que ocurren en la zona crítica (zona de interacción entre agua, suelo, aire, organismos), en este trabajo presentamos la distribución temporal y espacial de una secuencia de paleosuelos arcillosos con carbonatos secundarios (capas de caliches y carbonatos diseminados) en el sector nororiental de la Cuenca de México, particularmente en el valle de Teotihuacán. El propósito de este trabajo consiste en reconstruir la distribución temporal y espacial de la cubierta de suelos del pasado para entender su relación con la estructura actual de suelos y sedimentos en este sector semiárido de la cuenca de México. Con esta información, determinar la participación de estos materiales en la Zona Crítica (ZC). Para ello, se ha llevado a cabo un transecto de dirección norte-sur, que inicia en las elevaciones del Cerro Gordo, cruza el valle de Teotihuacán y termina en la Sierra Patlachique, describiendo perfiles de suelo en diferentes posiciones geomorfológicas. El marco cronológico se ha establecido con base en fechamientos de radiocarbono realizados en las capas de caliches. De acuerdo a la cronología, al tipo y grado de pedogénesis, y a los procesos de sedimentación, se han reconocido cuatro unidades. La primera unidad, denominada Paleosuelos del Pleistoceno, fase I (50000 – 20000 años AP), está compuesta de paleosuelos arcillosos, los cuales son Luvisoles crómicos y estágnicos, dependiendo de su posición en el paisaje. Estos paleosuelos muestran tanto carbonatos secundarios diseminados y en fracturas, como capas de caliches. En la segunda unidad, Paleosuelos del Pleistoceno, fase II (20000 –10000 años AP), dominan los sedimentos sobre los suelos; únicamente en el fondo del Valle, se han encontrado Gleysoles cortados por canales aluviales. La unidad, Paleosuelos del Holoceno, fase I (10000 a 1000 años AP) se caracteriza por presentar suelos poligenéticos (Vertisoles), fuertemente modificados por los procesos antrópicos, durante las diversas fases de ocupación pre-hispánica. La última unidad, Suelos del Holoceno, fase II, abarca el último milenio, en donde se destacan procesos de erosión e inestabilidad del paisaje. La tendencia principal en la distribución espacial de los paleosuelos es la siguiente: las unidades antiguas (Luvisoles, capas de caliches y Vertisoles) están sepultadas profundamente en el fondo del valle. Sin embargo, en los taludes y elevaciones montañosas, pueden aparecer cerca o directamente sobre la superficie, siendo incorporados en el manto de suelos actual. Las interrelaciones entre los diferentes paleosuelos a lo largo del transecto estudiado, junto con las observaciones micromorfológicas, apoyan la hipótesis de una relación evolutiva entre los Luvisoles pleistocénicos y los Vertisoles del Holoceno. Consideramos que estas diferentes unidades repercuten en los procesos hidrológicos en el valle y que las capas de caliche formadas en los ambientes pleistocénicos pueden afectar la geoquímica del agua subterránea así como sus firmas isotópicas. As soils are important elements for the processes involved in the critical zone (the zone of interaction between water, soil, air, and organisms), in this work we present the temporal and spatial distribution of a clayey-paleosol sequence with secondary carbonates (layers of caliche and disseminated carbonates) in the northeast sector of the Mexico Basin, particularly in the Teotihuacan Valley. The goal of this paper is the temporal and spatial reconstruction of the past soil cover to understand its relationship with the present day soils and sediments in this semiarid sector of the Mexico Basin. With this information the involvement of these materials in the critical zone could be determined. To comply with these objectives, a north-south transect was carried out, starting in the Cerro Gordo, crossing the Teotihuacan valley and ending in the Sierra Patlachique, describing soil profiles located in different geomorphological positions. The chronological framework has been established with radiocarbon dates of the caliche layers. According to this chronology, the type and degree of pedogenesis, as well as the sedimentation processes, four units have been recognized. The first unit is named the Pleistocene Paleosols, phase I (50000 – 20000 years BP), and is composed of clayey paleosols, chromic and stagnic Luvisols, depending on their position in the landscape. These paleosols contain pedogenic carbonates, disseminated and in fractures, and caliche layers. In the second unit, the Pleistocene Paleosols, phase II (20000 –10000 years BP), sediments predominate over soils; only in the valley floor some Gleysols are found to be cut by alluvial channels. The unit, Paleosols of the Holocene Paleosols unit, phase I (10000 to 1000 years BP), is characterized by polygenetic soils (Vertisols) strongly modified by anthropic processes during distinct phases of pre-hispanic occupation. The last unit, the Holocene Soils, phase II, covers the last millennium when erosional processes and unstable landscape dominate. The paleosols (Luvisols, caliche layers, and Vertisols) are deeply buried at the bottom of the valley. However, on the slopes and hilltop positions, they can appear close to or directly on the surface, being incorporated in the present day soil mantle. Spatial interrelations of different paleosols along the studied transect together with micromorphological observations support the hypothesis of an evolutionary link between the Pleistocene Luvisols and the Holocene Vertisols. We propose that these different units are involved in the hydrological processes in the valley and that the caliche layers, formed in the Pleistocene environments, can affect the geochemistry of the groundwater as well as its isotopic signatures.

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    Authors: Ambos, Kai;

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    Authors: Ambos, Kai;

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    Authors: Poblete, Hernán; Roffael, Edmone; Miertzsch, Helmut;

    Se determinó la disminución de la bioluminiscencia de bacterias como indicador de la actividad biológica de extractos de corteza. Se analizaron cuatro cortezas nativas chilenas. La reducción de la bioluminiscencia fue diferente dependiendo de la especie de corteza. El aumento del tiempo de un tratamiento térmico de la corteza (24, 48, 72 y 144 horas con 103ºC) produjo una reducción de la actividad biológica de los extractos. El estudio indica que los terpenos podrían ser responsables del efecto señalado Bioluminescence decrease of bacteria as a biological activity indicator for bark water extracts was determinate. Four Chilean barks were tested. A different reduction on bioluminescence depending on bark species was observed. Increasing time of thermal treatment of bark (24, 48, 72 and 144 hours with 103ºC) produced a reduction of the biological activity of extracts. The study indicates that the terpenes could be responsible for the described effect

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    Article . 2007
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      Article . 2007
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    Authors: García García, M.;

    Con el propósito de ampliar nuestro conocimiento acerca de la competencia conversacional en español como lengua extranjera y su enseñanza, este artículo analiza las características interactivas de la interlengua de once estudiantes de español participantes en nueve conversaciones. Los resultados del estudio ponen de manifiesto la falta de recursos de los hablantes no nativos a la hora de señalizar los procesos interactivos, así como una ausencia de iniciativa en el manejo de la interacción, lo que demuestra la necesidad de un enfoque explícito en la enseñanza de la conversación y asimismo la conveniencia de continuar la investigación en este campo. With the objective being to provide insights on the acquisition of second language conversational competence and its teaching, this paper analyzes the interactional features of the speech of eleven non-native speakers of Spanish in nine audiotaped conversations. Results of the study show learners' lack of resources to signal interactive processes as well as an absence of initiative in the management of interaction, which demonstrate the need for an explicit approach to conversation teaching and continued research in this field.

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