- publication . Patent . 2019Open Access HebrewAuthors:Šácha, P. (Pavel); Konvalinka, J. (Jan); Schimer, J. (Jiří); Knedlík, T. (Tomáš); Navrátil, V. (Václav); Tykvart, J. (Jan); Sedlák, F. (František); Majer, P. (Pavel); Cígler, P. (Petr); Šubr, V. (Vladimír); ...handle: 11104/0304601
The present invention describes macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used ...
- publication . Patent . 2019Open Access HebrewAuthors:Šácha, P. (Pavel); Konvalinka, J. (Jan); Schimer, J. (Jiří); Knedlík, T. (Tomáš); Šubr, V. (Vladimír); Ulbrich, K. (Karel); Strohalm, J. (Jiří);handle: 11104/0304600
The invention provides a synthetic macromolecular conjugate for selective interaction with proteins, comprising a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, said at least one bin...
- publication . Patent . 2016Open Access HebrewAuthors:Balzarini, J.; De Clercq, E.; Hocková, D. (Dana); Holý, A. (Antonín);handle: 11104/0269726
Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).
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