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846 research outcomes, page 1 of 85
  • publication . Preprint . Research . 2020
    Open Access English
    Authors:
    Fjell, Anders M.; Sørensen, Øystein; Amlien, Inge K.; Bartrés-Faz, David; Brandmaier, Andreas M.; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus P.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | Lifebrain (732592), CIHR , EC | CONSTRUCTIVEMEM (283634), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), WT | Wellcome Centre for Integ... (203139), RCUK | PREDICTING MRI ABNORMALIT... (G1001354), EC | Self-Control (677804), EC | AgeConsolidate (725025)

    Abstract Background Older persons with poor sleep are more likely to develop neurodegenerative disease, but the causality underlying this association is unclear. To move towards explanation, we examine whether sleep quality and quantity are similarly associated with bra...

  • publication . Article . 2016
    Open Access
    Authors:
    Matthews, Dawn C.; Lukic, Ana S.; Andrews, Randolph D.; Marendic, Boris; Brewer, James; Rissman, Robert A.; Mosconi, Lisa; Strother, Stephen C.; Wernick, Miles N.; Mobley, William C.; ...
    Publisher: Elsevier BV
    Project: CIHR , NSF | SBIR Phase II: Early and ... (1256638), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    AbstractIntroductionDown Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of ...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Wang, Yan; Chen, Kewei; Yao, Li; Jin, Zhen; Guo, Xiaojuan; the Alzheimer's Disease Neuroimaging Initiative;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | PET, APOE &The Preclinica... (5R01MH057899-09), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Neuromorphometry in Schiz... (5R01MH056584-11), CIHR , NIH | PET, APOE &the Preclinica... (9R01AG031581-10), NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NIH | STRUCTURE, FUNCTION AND C... (5P50MH071616-05), NIH | HEALTHY AGING AND SENILE ... (3P01AG003991-13S1), NIH | Functional-anatomic explo... (5R01AG021910-05),...

    Alzheimer’s disease (AD) is a well-known neurodegenerative disease that is associated with dramatic morphological abnormalities. The default mode network (DMN) is one of the most frequently studied resting-state networks. However, less is known about specific structural...

  • publication . Article . 2019
    Open Access
    Authors:
    Hao Hu; Ke-Liang Chen; Ya-Nan Ou; Xi-Peng Cao; Shi-Dong Chen; Mei Cui; Qiang Dong; Lan Tan; Jin-Tai Yu; null Alzheimer�s Disease Neuroimaging Initiative;
    Publisher: Impact Journals, LLC
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Previous studies demonstrated that plasma neurofilament light chain (NFL) played important predictive roles in disease progression and neurodegeneration in the preclinical phase of familial Alzheimer’s disease (AD). However, whether plasma NFL has the same predictive ro...

  • publication . Article . 2016
    Open Access English
    Authors:
    Bodily, Paul M.; Fujimoto, M. Stanley; Page, Justin T.; Clement, Mark J.; Ebbert, Mark T. W.; Ridge, Perry G.;
    Publisher: BioMed Central
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Background Genome-wide association studies (GWAS) have effectively identified genetic factors for many diseases. Many diseases, including Alzheimer’s disease (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants which together...

  • publication . Article . 2019
    Open Access English
    Authors:
    Damiano Archetti; Silvia Ingala; Vikram Venkatraghavan; Viktor Wottschel; Alexandra L. Young; Maura Bellio; Esther E. Bron; Stefan Klein; Frederik Barkhof; Daniel C. Alexander; ...
    Project: EC | EPAD (115736), NIH | MORPHOMETRY BIOMEDICAL IN... (5U24RR021382-04), EC | AMYPAD (115952), NIH | STRUCTURE, FUNCTION AND C... (5P50MH071616-05), NIH | Functional-anatomic explo... (5R01AG021910-05), EC | N4U (283562), EC | EuroPOND (666992), EC | CDS-QUAMRI (634541), NIH | HEALTHY AGING AND SENILE ... (3P01AG003991-13S1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01),...

    Understanding the sequence of biological and clinical events along the course of Alzheimer's disease provides insights into dementia pathophysiology and can help participant selection in clinical trials. Our objective is to train two data-driven computational models for...

  • publication . Article . 2019
    Open Access English
    Authors:
    Mei-Ling Tian; Xiao-Neng Ni; Jie-Qiong Li; Chen-Chen Tan; Xi-Peng Cao; Lan Tan; Lan Tan; for the Alzheimer’s Disease Neuroimaging Initiative;
    Publisher: Frontiers Media S.A.
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Background: rs9357347 located at the triggering receptor expressed on myeloid cells (TREM) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer’s disease (AD). Object...

  • publication . Article . 2012
    Open Access English
    Authors:
    Liyong Wu; Jared Rowley; Sara Mohades; Antoine Leuzy; Marina Tedeschi Dauar; Monica Shin; Vladimir Fonov; Jianping Jia; Serge Gauthier; Pedro Rosa-Neto; ...
    Publisher: Public Library of Science (PLoS)
    Project: CIHR , NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Background The hypothetical model of dynamic biomarkers for Alzheimer’s disease (AD) describes high amyloid deposition and hypometabolism at the mild cognitive impairment (MCI) stage. However, it remains unknown whether brain amyloidosis and hypometabolism follow the sa...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Karin Knesaurek; Geoffrey Warnock; Lale Kostakoglu; Cyrill Burger; null for Alzheimer′s Disease;
    Publisher: Medknow Publications & Media Pvt Ltd
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , WT

    Amyloid positron emission tomography (PET) imaging with florbetapir 18F (18F-AV-45) allows in vivo assessment of cerebral amyloid load and can be used in the evaluation of progression of Alzheimer's disease (AD) and other dementias associated with b-amyloid. However, co...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Gemma Salvadó; José Luis Molinuevo; Anna Brugulat-Serrat; Carles Falcon; Oriol Grau-Rivera; Marc Suárez-Calvet; Javier Pavia; Aida Niñerola-Baizán; Andrés Perissinotti; Francisco Lomeña; ...
    Publisher: BMC
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , EC | BioALFA (752310)

    Background The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for multicentre research studies and clinical trials...

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