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3 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Outi Maria Keinänen; Naga Vara Kishore Pillarsetty; Delphine Vivier; Anu Airaksinen; Mirkka P Sarparanta;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MICROPLATE SCINTILLATION/... (1S10RR013039-01), AKA | Pretargeted radiopharmace... (298481), NIH | MOUSE GENETICS (2P30CA008748-43), AKA | New radiolabeled molecula... (278056)

    Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and s...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Jason Lewis; Nerissa Viola; Linden Wyatt; Mirkka P Sarparanta;
    Publisher: American Chemical Society (ACS)
    Project: NIH | pHLIP-based agents for pr... (1F32CA186721-01A1), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET Imaging of Cancer wit... (5R01CA138468-04), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), AKA | New radiolabeled molecula... (278056)

    pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two pos...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Giuseppe Carlucci; Andreas Paulus; Thomas Reiner; Christian Brand;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (4TL1TR000459-10), NSF | IGERT: Returning the Radi... (0965983), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Background Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible with whole-body imaging techniques. The design of nov...

3 research outcomes, page 1 of 1
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