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19 research outcomes, page 1 of 2
  • publication . Article . 2017
    Open Access English
    Authors:
    Elizabeth V Wasmuth; John C Zinder; Dimitrios Zattas; Mom Das; Christopher D Lima;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural and Biochemica... (5F31GM097910-02)

    Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase. Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease Rrp6 a...

  • publication . Article . 2018
    Open Access English
    Authors:
    Maria Loressa Uson; Ayala Carl; Yehuda Goldgur; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | DNA Ligases in Mycobacter... (5R01AI064693-03), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01)

    Abstract Mycobacterium smegmatis FenA is a nucleic acid phosphodiesterase with flap endonuclease and 5′ exonuclease activities. The 1.8 Å crystal structure of FenA reported here highlights as its closest homologs bacterial FEN-family enzymes ExoIX, the Pol1 exonuclease ...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher Lima; Shaun Olsen; Michaelyn C. Lux; Zachary Hann;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Jia, Ning; Xie, Wei; de la Cruz, M. Jason; Eng, Edward T.; Patel, Dinshaw J.;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01)
  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Julia Batki; Jakob Schnabl; Juncheng Wang; Dominik Handler; Veselin I. Andreev; Christian E. Stieger; Maria Novatchkova; Lisa Lampersberger; Kotryna Kauneckaite; Wei Xie; ...
    Project: FWF | RNA Biology (W 1207), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), EC | PIWI-Chrom (682181)

    <jats:title>ABSTRACT</jats:title><jats:p>The PIWI-interacting RNA (piRNA) pathway protects animal genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent t...

  • publication . Article . 2018
    Open Access
    Authors:
    Ankan Banerjee;
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01)
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Gerard Minuesa; Steven K. Albanese; Wei Xie; Yaniv Kazansky; Daniel Worroll; Arthur Chow; Alexandra Schurer; Sun-Mi Park; Christina Z. Rotsides; James Taggart; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Characterizing MSI2 in le... (5R01CA193842-02), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Huang, Hongda; Deng, Zhong; Vladimirova, Olga; Wiedmer, Andreas; Lu, Fang; Lieberman, Paul M.; Patel, Dinshaw J.;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | CONSOLIDATED BASIC CANCER... (5P30CA010815-28), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Chromatin Regulation of K... (1P01CA174439-01A1)

    The histone H3.3 chaperone DAXX is implicated in formation of heterochromatin and transcription silencing, especially for newly infecting DNA virus genomes entering the nucleus. Epstein-Barr virus (EBV) can efficiently establish stable latent infection as a chromatinize...

  • publication . Article . 2017
    Open Access English
    Authors:
    Elizabeth A Hubin; Allison Fay; Catherine Xu; James M Bean; Ruth M Saecker; Michael S Glickman; Seth A Darst; Elizabeth A Campbell;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Crystallization Robot for... (1S10RR027037-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structure/function analys... (5R01GM114450-02), NIH | Pixel Array Detector for ... (1S10RR029205-01)

    RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2 is likely a bottl...

  • publication . Article . 2017
    Open Access
    Authors:
    Remus, Barbara S.; Goldgur, Yehuda; Shuman, Stewart;
    Publisher: Oxford University Press (OUP)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

19 research outcomes, page 1 of 2
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