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8 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ryan M. Williams; Christopher Lee; Thomas V. Galassi; Jackson D. Harvey; Rachel Leicher; Maria Sirenko; Madeline A. Dorso; Janki Shah; Narciso Olvera; Fanny Dao; ...
    Publisher: American Association for the Advancement of Science
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    Ovarian cancer biomarker detection using a novel nanosensor implant in live mice.

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Josef Leibold; Daniel A Heller; Darren Johnson; Rajasekhar Vinagolu; Daniel Roxbury; Mehtap Işık; Januka Budhathoki-Uprety;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | PROTEOLYTIC CONTROL OF ON... (2P01CA013106-31), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe herein a targeted dru...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Ryan M. Williams; Janki Shah; Elizabeth Mercer; Helen S. Tian; Justin M. Cheung; Madeline Dorso; Edgar A. Jaimes; Daniel A. Heller;
    Publisher: Cold Spring Harbor Laboratory
    Project: NSF | CAREER: A Quantitative Na... (1752506), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    <jats:title>Abstract</jats:title><jats:p>Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower survival and increased economic burden, there is no pharmacolo...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Daniel Roxbury; Daniel A Heller; Prakrit Jena; Januka Budhathoki-Uprety;
    Publisher: American Chemical Society
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    The use of single-walled carbon nanotubes (SWCNTs) as near-infrared optical probes and sensors require the ability to simultaneously modulate nanotube fluorescence and functionally derivatize the nanotube surface using noncovalent methods. We synthesized a small library...

  • publication . Preprint . Article . Other literature type . 2017
    Open Access
    Authors:
    Jena, Prakrit V.; Roxbury, Daniel; Galassi, Thomas V.; Akkari, Leila; Horoszko, Christopher P.; Iaea, David B.; Budhathoki-Uprety, Januka; Pipalia, Nina H.; Haka, Abigail S.; Harvey, Jackson D.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Macrophage-lipoprotein in... (5R01HL093324-02), NIH | Investigating and Targeti... (1R01CA181355-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Endogenous Heterogeneity ... (5U54CA148967-02), NIH | Cancer Pharmacology (2T32CA062948-21), NIH | Transient Metabolite Dete... (1DP2HD075698-01), NIH | Receptor-mediated Endocyt... (5R37DK027083-36), NIH | Bioinformatics Core (2P20GM103430-14), NIH | Structure-function studie... (1F31DK104631-01)

    <jats:title>ABSTRACT</jats:title><jats:p>Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot me...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Philipp Niethammer; Balázs Enyedi; Daniel Roxbury; Daniel A Heller; Prakrit Jena;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    The intrinsic near-infrared photoluminescence (fluorescence) of single-walled carbon nanotubes exhibits unique photostability, narrow bandwidth, penetration through biological media, environmental sensitivity, and both chromatic variety and range. Biomedical application...

  • publication . Article . 2017
    Open Access
    Authors:
    Rajasekhar Vinagolu; Daniel A Heller; Samuel Brook;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    Alterations in PIK3CA, the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas. Inhibitors of PI3Kα show promising activity in various cancer types, but their use is curtailed by dose-limiting ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Budhathoki-Uprety, Januka; Shah, Janki; Korsen, Joshua A.; Wayne, Alysandria E.; Galassi, Thomas V.; Cohen, Joseph R.; Harvey, Jackson D.; Jena, Prakrit V.; Ramanathan, Lakshmi V.; Jaimes, Edgar A.; ...
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Renal tubule-specific nan... (1R01DK114321-01A1), NSF | CAREER: A Quantitative Na... (1752506), NIH | Transient Metabolite Dete... (1DP2HD075698-01)

    Microalbuminuria is an important clinical marker of several cardiovascular, metabolic, and other diseases such as diabetes, hypertension, atherosclerosis, and cancer. The accurate detection of microalbuminuria relies on albumin quantification in the urine, usually via a...

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