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7 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher Lima; Shaun Olsen; Michaelyn C. Lux; Zachary Hann;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Ceraudo, Emilie; Horioka, Mizuho; Mattheisen, Jordan M.; Hitchman, Tyler D.; Moore, Amanda R.; Kazmi, Manija A.; Chi, Ping; Chen, Yu; Sakmar, Thomas P.; Huber, Thomas;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | An integrative approach t... (1DP2CA174499-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Administrative Core (5P50CA140146-04), NIH | RATIONAL DESIGN OF PROSTA... (5P50CA092629-10), NIH | Understanding the roles o... (1K08CA140946-01), NIH | Defining the Role of ERG ... (5R01CA193837-02), NIH | Elucidating the roles of ... (5K08CA151660-05)

    <jats:title>Abstract</jats:title><jats:p>The G protein-coupled receptor (GPCR) cysteinyl-leukotriene receptor 2 (CysLTR2) with a single amino acid mutation at position 3.43 (Leu replaced with Gln at position 129 in transmembrane helix 3) causes uveal melanoma in humans....

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Zheng, Qingfei; Osunsade, Adewola; David, Yael;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Application of intein-bas... (1R21DA044767-01A1)

    Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with general chromatin decompaction and...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Marian Okondo; Sahana Rao; Ashley Chui;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Abstract Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which recruit and activate caspase-1 and trigger an inflammatory form of cell death called pyroptosis. The well-characterized mammalian inflammasome sensor proteins all ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Albert Agustinus; Hannah K. D'Ambrosio; Bo Liu; Nathaniel Omans; Adewola Osunsade;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Tri-Institutional Trainin... (5T32GM083937-05)

    Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in brea...

  • publication . Article . 2017
    Open Access
    Authors:
    Martin Lepsik; Anežka Tichá; Petr Pachl; Darren Johnson; Stancho Stanchev;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), RCUK | Membrane protein structur... (MC_U105184322), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), EC | RHOMBOID SUBSTRATES (304154)

    Summary Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeuti...

  • publication . Article . 2018
    Open Access English
    Authors:
    Johnson, Darren C.; Taabazuing, Cornelius Y.; Okondo, Marian C.; Chui, Ashley J.; Rao, Sahana D.; Brown, Fiona C.; Reed, Casie; Peguero, Elizabeth; de Stanchina, Elisa; Kentsis, Alex; ...
    Project: NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in ...

7 research outcomes, page 1 of 1
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