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6 research outcomes, page 1 of 1
  • publication . Preprint . Article . 2017
    Open Access English
    Authors:
    Kavitha Ramaswamy; Lauren Forbes; Gerard Minuesa; Tatyana Gindin; Fiona Brown; Michael G. Kharas; Andrei V. Krivtsov; Scott A. Armstrong; Eric Still; Elisa de Stanchina; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Characterizing MSI2 in le... (5R01CA193842-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | Epigenetic mechanisms of ... (1K08CA191091-01A1), NIH | Predoctoral Training in P... (1T32GM073546-01A1)

    Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. Using structure-guided molec...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Fiona C. Brown; Eric Still; Paolo Cifani; Sumiko Takao; Casie Reed; Scott B. Ficarro; Richard P. Koche; Peter Romanienko; Willie Mark; Conor O’Donnell; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant signaling in acu... (5R01CA204396-03)

    <jats:sec><jats:title>HIGHLIGHTS</jats:title><jats:p><jats:list list-type="bullet"><jats:list-item><jats:p>MEF2C S222 phosphorylation is a specific marker of chemotherapy resistance in diagnostic AML patient specimens.</jats:p></jats:list-item><jats:list-item><jats:p>ME...

  • publication . Preprint . 2016
    Open Access
    Authors:
    Brown, Fiona C.; Cifani, Paolo; Drill, Esther; He, Jie; Still, Eric; Zhong, Shan; Balasubramanian, Sohail; Pavlick, Dean; Yilmazel, Bahar; Knapp, Kristina M.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Children's Oncology Group... (5U10CA180899-04)

    <jats:title>Abstract</jats:title><jats:p>Despite intense efforts, the cure rates of children and adults with AML remain unsatisfactory in large part due to resistance to chemotherapy. Whilst cytogenetic risk stratification proved valuable in identifying causes of therap...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Akihide Yoshimi; Alex Kentsis; Paolo Cifani;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Phosphoproteomic signatur... (5R21CA188881-02)

    <jats:title>SUMMARY</jats:title><jats:p>Modern mass spectrometry now permits genome-scale and quantitative measurements of biological proteomes. However, analyses of specific specimens are currently hindered by the incomplete representation of biological variability of ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Johnson, Darren C.; Taabazuing, Cornelius Y.; Okondo, Marian C.; Chui, Ashley J.; Rao, Sahana D.; Brown, Fiona C.; Reed, Casie; Peguero, Elizabeth; de Stanchina, Elisa; Kentsis, Alex; ...
    Project: NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in ...

  • publication . Other literature type . Article . Preprint . 2016
    Open Access English
    Authors:
    Paolo Cifani;
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:sec><jats:title>Abbreviations</jats:title><jats:def-list><jats:def-item><jats:term>DDA</jats:term><jats:def><jats:p>Data Dependent Acquisition</jats:p></jats:def></jats:def-item><jats:def-item><jats:term>DIA</jats:term><jats:def><jats:p>Data Independent Acquisitio...

6 research outcomes, page 1 of 1
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