Download Results
1 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Jessica J. Tao; Ying Zhang; David M. Hyman; David M. Hyman; Nathaniel A. Outmezguine; Na Na; Gideon Bollag; Huiyong Zhao; Rory Mcgriskin; Chao Zhang; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Studies on oncoprotein-in... (5R35CA210085-02), NIH | Mechanisms and Modulators... (5P01CA129243-07), NIH | Cancer Chemotherapy Train... (5T32CA009207-29)

    Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can function as active monomers1. Current RAF inhibitors are monomer selective, they potently inhibit BRAF V600 monomers but t...

1 research outcomes, page 1 of 1