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PublicationsOpen AccessMOUSE GENETICSAberrant signaling in acute myeloi...Characterizing the Mechanism of DP...
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  • publication . Article . 2018
    DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
    Open Access English
    Authors:
    Johnson, Darren C.; Taabazuing, Cornelius Y.; Okondo, Marian C.; Chui, Ashley J.; Rao, Sahana D.; Brown, Fiona C.; Reed, Casie; Peguero, Elizabeth; de Stanchina, Elisa; Kentsis, Alex; ...
    doi: 10.1038/s41591-018-0082-y
    Project: NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Characterizing the Mechan... (1R01AI137168-01), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in ...

1 research outcomes, page 1 of 1