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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Marian C. Okondo; Ashley J. Chui; Daniel A. Bachovchin; Daniel A. Bachovchin; Daniel P. Ball; Darren C. Johnson; Kuo Gai; Sahana D. Rao;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Characterizing the Mechan... (1R01AI137168-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01)

    Abstract Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which recruit and activate caspase-1 and trigger an inflammatory form of cell death called pyroptosis. The well-characterized mammalian inflammasome sensor proteins all ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Johnson, Darren C.; Taabazuing, Cornelius Y.; Okondo, Marian C.; Chui, Ashley J.; Rao, Sahana D.; Brown, Fiona C.; Reed, Casie; Peguero, Elizabeth; de Stanchina, Elisa; Kentsis, Alex; ...
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | Characterizing the Mechan... (1R01AI137168-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01)

    Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in ...

  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Andrew R. Griswold; Brooke A. Vittimberga; Sahana D. Rao; Kuo Gai; Ashley J. Chui; Marian C. Okondo; Daniel A. Bachovchin;
    Publisher: bioRxiv
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Characterizing the Mechan... (1R01AI137168-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptotic cell death. The anthrax lethal factor metalloprotease and small molecule DPP8/9 inhibit...

  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Daniel P. Ball; Darren C. Johnson; Daniel A. Bachovchin; Daniel A. Bachovchin; Cornelius Y. Taabazuing; Ilana B. Kotliar; Elizabeth L. Orth; Andrew R. Griswold; Sahana D. Rao;
    Publisher: bioRxiv
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    <jats:title>Abstract</jats:title><jats:p>Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied PRRs oligomerize with th...

  • publication . Article . 2020
    Open Access English
    Authors:
    Ball, Daniel P; Taabazuing, Cornelius Y; Griswold, Andrew R; Orth, Elizabeth L; Rao, Sahana D; Kotliar, Ilana B; Vostal, Lauren E; Johnson, Darren C; Bachovchin, Daniel A;
    Publisher: Life Science Alliance LLC
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied inflammasome-forming PRRs oligomerize with the adapter protein AS...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Abir Bhattacharjee; Daniel A. Bachovchin; Daniel A. Bachovchin; Cornelius Y. Taabazuing; Sahana D. Rao; Andrew R. Griswold; Andrew R. Griswold; Daniel P. Ball; Ashley J. Chui;
    Publisher: American Chemical Society
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors ...

6 research outcomes, page 1 of 1