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PublicationsOpen AccessMOUSE GENETICSCharacterizing the Mechanism of DP...bioRxiv
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2 research outcomes, page 1 of 1
  • publication . Other literature type . Preprint . 2018
    N-terminal degradation activates the Nlrp1b inflammasome
    Open Access
    Authors:
    Andrew R. Griswold; Brooke A. Vittimberga; Sahana D. Rao; Kuo Gai; Ashley J. Chui; Marian C. Okondo; Daniel A. Bachovchin;
    doi: 10.1101/317826
    Publisher: bioRxiv
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Characterizing the Mechan... (1R01AI137168-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptotic cell death. The anthrax lethal factor metalloprotease and small molecule DPP8/9 inhibit...

  • publication . Other literature type . Preprint . 2019
    Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation
    Open Access
    Authors:
    Daniel P. Ball; Darren C. Johnson; Daniel A. Bachovchin; Daniel A. Bachovchin; Cornelius Y. Taabazuing; Ilana B. Kotliar; Elizabeth L. Orth; Andrew R. Griswold; Sahana D. Rao;
    doi: 10.1101/681304
    Publisher: bioRxiv
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    <jats:title>Abstract</jats:title><jats:p>Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied PRRs oligomerize with th...

2 research outcomes, page 1 of 1