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PublicationsOpen AccessMOUSE GENETICSCharacterizing the Mechanism of DP...ACS Chemical Biology
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  • publication . Other literature type . Article . 2019
    DPP9’s Enzymatic Activity and Not Its Bindingto CARD8 Inhibits Inflammasome Activation
    Open Access
    Authors:
    Abir Bhattacharjee; Daniel A. Bachovchin; Daniel A. Bachovchin; Cornelius Y. Taabazuing; Sahana D. Rao; Andrew R. Griswold; Andrew R. Griswold; Daniel P. Ball; Ashley J. Chui;
    doi: 10.1021/acschembio.9b00462
    Publisher: American Chemical Society (ACS)
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors ...

1 research outcomes, page 1 of 1