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5 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Marian Okondo; Sahana Rao; Ashley Chui;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Abstract Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which recruit and activate caspase-1 and trigger an inflammatory form of cell death called pyroptosis. The well-characterized mammalian inflammasome sensor proteins all ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Johnson, Darren C.; Taabazuing, Cornelius Y.; Okondo, Marian C.; Chui, Ashley J.; Rao, Sahana D.; Brown, Fiona C.; Reed, Casie; Peguero, Elizabeth; de Stanchina, Elisa; Kentsis, Alex; ...
    Project: NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in ...

  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Daniel P. Ball; Cornelius Y. Taabazuing; Andrew R. Griswold; Elizabeth L. Orth; Sahana D. Rao; Ilana B. Kotliar; Darren C. Johnson; Daniel A. Bachovchin;
    Publisher: bioRxiv
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    <jats:title>Abstract</jats:title><jats:p>Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied PRRs oligomerize with th...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Ashley J. Chui; Marian C. Okondo; Sahana D. Rao; Kuo Gai; Andrew R. Griswold; Darren C. Johnson; Daniel P. Ball; Cornelius Y. Taabazuing; Elizabeth L. Orth; Brooke A. Vittimberga; ...
    Publisher: American Association for the Advancement of Science (AAAS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Characterizing the Mechan... (1R01AI137168-01)

    <jats:p>Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, b...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Andrew R. Griswold; Daniel P. Ball; Abir Bhattacharjee; Ashley J. Chui; Sahana D. Rao; Cornelius Y. Taabazuing; Daniel A. Bachovchin;
    Publisher: American Chemical Society
    Project: NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing the Mechan... (1R01AI137168-01)

    Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors ...

5 research outcomes, page 1 of 1
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