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3 research outcomes, page 1 of 1
  • publication . Article . 2018
    Open Access English
    Authors:
    Garg, Angad; Goldgur, Yehuda; Schwer, Beate; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | mRNA Capping Enzyme (2R01GM052470-09), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Pho7, a member of the Zn2Cys6 family of fungal transcription factors, is the key transcriptional activator underlying fission yeast phosphate homeostasis, a physiological response to phosphate starvation in which the pho1, pho84 and tgp1 genes are upregulated. ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Banerjee, Ankan; Ghosh, Shreya; Goldgur, Yehuda; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2020
    Open Access English
    Authors:
    Shreya Ghosh; Yehuda Goldgur; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01), NIH | DNA Ligases in Mycobacter... (5R01AI064693-03)

    <jats:title>Abstract</jats:title> <jats:p>Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activit...

3 research outcomes, page 1 of 1