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PublicationsOpen AccessMOUSE GENETICSCharacterizing MSI2 in leukemiaNE-CAT Center for Advanced Macromo...
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  • publication . Article . Other literature type . 2019
    Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
    Open Access English
    Authors:
    Michael G. Kharas; Fraser Glickman; Gerard Minuesa; Sun Mi Park; Carolina Adura; Saroj Gourkanti; Levi N. Naden; Christina S. Leslie; Steven K. Albanese; Wei Xie; ...
    doi: 10.1038/s41467-019-10523-3
    pmc: PMC6584500
    pmid: 31217428
    Publisher: Nature Publishing Group
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing MSI2 in le... (5R01CA193842-02)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

1 research outcomes, page 1 of 1