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2 research outcomes, page 1 of 1
  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Levi N. Naden; Joseph K. Eibl; Fraser Glickman; Christopher Famulare; Saroj Gourkanti; Arthur Chow; John D. Chodera; Andrea Rizzi; Christina Z. Rotsides; Steven K. Albanese; ...
    Publisher: American Society of Hematology
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Uncovering the role for M... (5R01DK101989-03)

    <jats:title>Abstract</jats:title> <jats:p>RNA-binding proteins (RBPs) play critical roles in cell homeostasis by controlling gene expression post-transcriptionally, contributing to mRNA processing events (splicing, polyadenylation, localization, stability, export and tr...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Michael G. Kharas; Fraser Glickman; Gerard Minuesa; Sun Mi Park; Carolina Adura; Saroj Gourkanti; Levi N. Naden; Christina S. Leslie; Steven K. Albanese; Wei Xie; ...
    Publisher: Nature Publishing Group
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing MSI2 in le... (5R01CA193842-02)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

2 research outcomes, page 1 of 1