Advanced search
Filters (4 )
Filters
Clear All
PublicationsOpen AccessMOUSE GENETICSCrystallization Robot for the Stru...NE-CAT Center for Advanced Macromo...
Download Results
2 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2018
    Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
    Open Access
    Authors:
    Aleksandr Milshteyn; Nathaniel R. Braffman; Allison Fay; John B. Biggins; Mirjana Lilic; Sean F. Brady; James Peek; Seth A. Darst; Ian D. Woodworth; Michael S. Glickman; ...
    doi: 10.1038/s41467-018-06587-2
    pmid: 30297823
    pmc: PMC6175910
    Publisher: Springer Nature America, Inc
    Project: NIH | Discovery of Antibiotics ... (1R35GM122559-01), NIH | Structure/function analys... (5R01GM114450-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | A minimally invasive synt... (1U01GM110714-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structure, function, and ... (5R35GM118130-02), NIH | Crystallization Robot for... (1S10RR027037-01)

    Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a d...

  • publication . Article . 2017
    Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA
    Open Access English
    Authors:
    Hubin, Elizabeth A; Fay, Allison; Xu, Catherine; Bean, James M; Saecker, Ruth M; Glickman, Michael S; Darst, Seth A; Campbell, Elizabeth A;
    doi: 10.7554/elife.22520
    pmc: PMC5302886
    pmid: 28067618
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Structure/function analys... (5R01GM114450-02), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Crystallization Robot for... (1S10RR027037-01)

    RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2 is likely a bottl...

2 research outcomes, page 1 of 1