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3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Frederick C. Streich; Christopher D. Lima; Christopher D. Lima;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    Summary Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear an...

  • publication . Article . 2015
    Open Access English
    Authors:
    Cappadocia, Laurent; Pichler, Andrea; Lima, Christopher D.;
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | Macromolecular Crystallog... (3P41GM103473-16S2), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Macromolecular Crystallog... (3P41RR012408-15S1)

    E3 protein ligases enhance transfer of ubiquitin-like (Ubl) proteins from E2 conjugating enzymes to substrates by stabilizing the thioester-charged E2~Ubl in a closed configuration optimally aligned for nucleophilic attack. Here, we report biochemical and structural dat...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Derek S. Tan; Derek S. Tan; Christopher D. Lima; Christopher D. Lima; Zachary S. Hann; Zachary S. Hann; Xuequan Lu; Michaelyn C. Lux; Michaelyn C. Lux; Shaun K. Olsen; ...
    Publisher: National Academy of Sciences
    Project: NIH | Structural and Functional... (5R01GM079196-07), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

3 research outcomes, page 1 of 1