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Clear All- publication . Article . Other literature type . 2017Open AccessAuthors:Hongda Huang; Hongda Huang; Aayushi Y Jain; Dinshaw J. Patel; Dominik Hoelper; Peter W. Lewis;pmc: PMC5662737pmid: 29084956Publisher: Springer NatureProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)
The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...
- publication . Article . 2020Open Access EnglishAuthors:Shreya Ghosh; Yehuda Goldgur; Stewart Shuman;doi: 10.1093/nar/gkaa075pmc: PMC7102940pmid: 32034423Publisher: Oxford University PressProject: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01), NIH | DNA Ligases in Mycobacter... (5R01AI064693-03)
<jats:title>Abstract</jats:title> <jats:p>Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activit...
- publication . Article . Other literature type . 2018Open AccessAuthors:Akiko Koide; Stephen B. Long; Shohei Koide; Leanne Pedi; Melinda M. Diver;doi: 10.1038/nature25439pmc: PMC5785467pmid: 29342140Publisher: Springer Science and Business Media LLCProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Bridge 1: Conformational ... (2U54GM087519-06), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43)
The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytoso...
- publication . Article . 2019Open Access EnglishAuthors:Hann, Zachary S.; Metzger, Meredith B.; Weissman, Allan M.; Lima, Christopher D.;pmc: PMC6688661pmid: 31397327Publisher: International Union of CrystallographyProject: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)
A 1.7 Å resolution co-crystal structure of U7BR from Schizosaccharomyces pombe in complex with Ubc7 is reported. Structural comparisons and biochemistry suggest that U7BR presents a steric impediment to E1 binding and inhibits E1-mediated charging, respectively.
- publication . Preprint . Article . Other literature type . 2018Open Access EnglishAuthors:Xiaowei Hou; Stephen B. Long; Shana R. Burstein;Publisher: Cold Spring Harbor LaboratoryProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | 3D Structure and Function... (2R01GM094273-06)
<jats:title>Abstract</jats:title><jats:p>The store-operated calcium (Ca<jats:sup>2+</jats:sup>) channel Orai governs Ca<jats:sup>2+</jats:sup> influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to depletion of Ca<j...
- publication . Article . Other literature type . Preprint . 2018Open AccessAuthors:Levi N. Naden; Joseph K. Eibl; Fraser Glickman; Christopher Famulare; Saroj Gourkanti; Arthur Chow; John D. Chodera; Andrea Rizzi; Christina Z. Rotsides; Steven K. Albanese; ...Publisher: American Society of HematologyProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Uncovering the role for M... (5R01DK101989-03)
<jats:title>Abstract</jats:title> <jats:p>RNA-binding proteins (RBPs) play critical roles in cell homeostasis by controlling gene expression post-transcriptionally, contributing to mRNA processing events (splicing, polyadenylation, localization, stability, export and tr...
- publication . Article . Other literature type . 2017Open Access EnglishAuthors:Tasos Gogakos; Tasos Gogakos; J. Fraser Glickman; Antonio Luz; Antonio Luz; Thomas Tuschl; Thomas Tuschl; Jessica Vincent; Rei Okamoto; Jumpei Aida; ...pmc: PMC5622107pmid: 28963528Publisher: Nature Publishing Group UKProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Posttranscriptional regul... (5R01GM104962-02)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...
- publication . Article . 2017Open Access EnglishAuthors:Yehuda Goldgur; Barbara S. Remus; Stewart Shuman;doi: 10.1093/nar/gkx1159pmc: PMC5728400pmid: 29165709Publisher: Oxford University PressProject: NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)
Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...
- publication . Article . 2018Open Access EnglishAuthors:Banerjee, Ankan; Ghosh, Shreya; Goldgur, Yehuda; Shuman, Stewart;doi: 10.1093/nar/gky1275pmc: PMC6379707pmid: 30590734Publisher: Oxford University PressProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)
Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...
- publication . Article . 2017Open AccessAuthors:Wenfu Ma; Elena Goldberg; Jonathan Goldberg; Jonathan Goldberg;doi: 10.7554/elife.26624pmid: 28594326pmc: PMC5464768Publisher: eLife Sciences Publications, LtdProject: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03)
Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostas...
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