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21 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Hongda Huang; Hongda Huang; Aayushi Y Jain; Dinshaw J. Patel; Dominik Hoelper; Peter W. Lewis;
    Publisher: Springer Nature
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...

  • publication . Article . 2020
    Open Access English
    Authors:
    Shreya Ghosh; Yehuda Goldgur; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01), NIH | DNA Ligases in Mycobacter... (5R01AI064693-03)

    <jats:title>Abstract</jats:title> <jats:p>Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activit...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Akiko Koide; Stephen B. Long; Shohei Koide; Leanne Pedi; Melinda M. Diver;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Bridge 1: Conformational ... (2U54GM087519-06), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytoso...

  • publication . Article . 2019
    Open Access English
    Authors:
    Hann, Zachary S.; Metzger, Meredith B.; Weissman, Allan M.; Lima, Christopher D.;
    Publisher: International Union of Crystallography
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    A 1.7 Å resolution co-crystal structure of U7BR from Schizosaccharomyces pombe in complex with Ubc7 is reported. Structural comparisons and biochemistry suggest that U7BR presents a steric impediment to E1 binding and inhibits E1-mediated charging, respectively.

  • publication . Preprint . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiaowei Hou; Stephen B. Long; Shana R. Burstein;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | 3D Structure and Function... (2R01GM094273-06)

    <jats:title>Abstract</jats:title><jats:p>The store-operated calcium (Ca<jats:sup>2+</jats:sup>) channel Orai governs Ca<jats:sup>2+</jats:sup> influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to depletion of Ca<j...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Levi N. Naden; Joseph K. Eibl; Fraser Glickman; Christopher Famulare; Saroj Gourkanti; Arthur Chow; John D. Chodera; Andrea Rizzi; Christina Z. Rotsides; Steven K. Albanese; ...
    Publisher: American Society of Hematology
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Uncovering the role for M... (5R01DK101989-03)

    <jats:title>Abstract</jats:title> <jats:p>RNA-binding proteins (RBPs) play critical roles in cell homeostasis by controlling gene expression post-transcriptionally, contributing to mRNA processing events (splicing, polyadenylation, localization, stability, export and tr...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Tasos Gogakos; Tasos Gogakos; J. Fraser Glickman; Antonio Luz; Antonio Luz; Thomas Tuschl; Thomas Tuschl; Jessica Vincent; Rei Okamoto; Jumpei Aida; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Posttranscriptional regul... (5R01GM104962-02)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

  • publication . Article . 2017
    Open Access English
    Authors:
    Yehuda Goldgur; Barbara S. Remus; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2018
    Open Access English
    Authors:
    Banerjee, Ankan; Ghosh, Shreya; Goldgur, Yehuda; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2017
    Open Access
    Authors:
    Wenfu Ma; Elena Goldberg; Jonathan Goldberg; Jonathan Goldberg;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03)

    Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostas...

21 research outcomes, page 1 of 3