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3 research outcomes, page 1 of 1
  • publication . Article . 2017
    ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.
    Open Access
    Authors:
    Wenfu Ma; Elena Goldberg; Jonathan Goldberg; Jonathan Goldberg;
    doi: 10.7554/elife.26624
    pmid: 28594326
    pmc: PMC5464768
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03)

    Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostas...

  • publication . Article . 2017
    Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.
    Open Access English
    Authors:
    John C. Zinder; Mom Das; Christopher D. Lima; Elizabeth V. Wasmuth; Dimitrios Zattas;
    doi: 10.7554/elife.29062
    pmc: PMC5553935
    pmid: 28742025
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Structural and Functional... (5R01GM079196-07), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | Structural and Biochemica... (5F31GM097910-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase. Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease Rrp6 a...

  • publication . Preprint . Article . Other literature type . 2018
    Structures Reveal Opening of the Store-Operated Calcium Channel ORAI
    Open Access English
    Authors:
    Xiaowei Hou; Stephen B. Long; Shana R. Burstein;
    doi: 10.1101/284034 , 10.1016/j.bpj.2018.11.1637 , 10.7554/elife.36758
    View all 5 identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | 3D Structure and Function... (2R01GM094273-06)

    <jats:title>Abstract</jats:title><jats:p>The store-operated calcium (Ca<jats:sup>2+</jats:sup>) channel Orai governs Ca<jats:sup>2+</jats:sup> influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to depletion of Ca<j...

3 research outcomes, page 1 of 1