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11 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Aleksandr Milshteyn; Nathaniel R. Braffman; Allison Fay; John B. Biggins; Mirjana Lilic; Sean F. Brady; James Peek; Seth A. Darst; Ian D. Woodworth; Michael S. Glickman; ...
    Publisher: Springer Nature America, Inc
    Project: NIH | Discovery of Antibiotics ... (1R35GM122559-01), NIH | Structure/function analys... (5R01GM114450-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | A minimally invasive synt... (1U01GM110714-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structure, function, and ... (5R35GM118130-02), NIH | Crystallization Robot for... (1S10RR027037-01)

    Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a d...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Derek S. Tan; Derek S. Tan; Christopher D. Lima; Christopher D. Lima; Zachary S. Hann; Zachary S. Hann; Xuequan Lu; Michaelyn C. Lux; Michaelyn C. Lux; Shaun K. Olsen; ...
    Publisher: National Academy of Sciences
    Project: NIH | Structural and Functional... (5R01GM079196-07), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Hongda Huang; Hongda Huang; Aayushi Y Jain; Dinshaw J. Patel; Dominik Hoelper; Peter W. Lewis;
    Publisher: Springer Nature
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Akiko Koide; Stephen B. Long; Shohei Koide; Leanne Pedi; Melinda M. Diver;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Bridge 1: Conformational ... (2U54GM087519-06), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytoso...

  • publication . Preprint . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiaowei Hou; Stephen B. Long; Shana R. Burstein;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | 3D Structure and Function... (2R01GM094273-06)

    <jats:title>Abstract</jats:title><jats:p>The store-operated calcium (Ca<jats:sup>2+</jats:sup>) channel Orai governs Ca<jats:sup>2+</jats:sup> influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to depletion of Ca<j...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Levi N. Naden; Joseph K. Eibl; Fraser Glickman; Christopher Famulare; Saroj Gourkanti; Arthur Chow; John D. Chodera; Andrea Rizzi; Christina Z. Rotsides; Steven K. Albanese; ...
    Publisher: American Society of Hematology
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Characterizing MSI2 in le... (1R01CA193842-01), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Uncovering the role for M... (5R01DK101989-03)

    <jats:title>Abstract</jats:title> <jats:p>RNA-binding proteins (RBPs) play critical roles in cell homeostasis by controlling gene expression post-transcriptionally, contributing to mRNA processing events (splicing, polyadenylation, localization, stability, export and tr...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Tasos Gogakos; Tasos Gogakos; J. Fraser Glickman; Antonio Luz; Antonio Luz; Thomas Tuschl; Thomas Tuschl; Jessica Vincent; Rei Okamoto; Jumpei Aida; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Posttranscriptional regul... (5R01GM104962-02)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Frederick C. Streich; Christopher D. Lima; Christopher D. Lima;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    Summary Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear an...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Michael G. Kharas; Fraser Glickman; Gerard Minuesa; Sun Mi Park; Carolina Adura; Saroj Gourkanti; Levi N. Naden; Christina S. Leslie; Steven K. Albanese; Wei Xie; ...
    Publisher: Nature Publishing Group
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing MSI2 in le... (5R01CA193842-02)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Zhong Deng; Hongda Huang; Paul M. Lieberman; Fang Lu; Andreas Wiedmer; Dinshaw J. Patel; Olga Vladimirova;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | CONSOLIDATED BASIC CANCER... (5P30CA010815-28), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Chromatin Regulation of K... (1P01CA174439-01A1)

    The histone H3.3 chaperone DAXX is implicated in formation of heterochromatin and transcription silencing, especially for newly infecting DNA virus genomes entering the nucleus. Epstein-Barr virus (EBV) can efficiently establish stable latent infection as a chromatinize...

11 research outcomes, page 1 of 2