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3 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.
    Open Access
    Authors:
    Hongda Huang; Hongda Huang; Aayushi Y Jain; Dinshaw J. Patel; Dominik Hoelper; Peter W. Lewis;
    doi: 10.1038/s41467-017-01206-y
    pmc: PMC5662737
    pmid: 29084956
    Publisher: Springer Nature
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...

  • publication . Article . Other literature type . 2017
    Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
    Open Access English
    Authors:
    Tasos Gogakos; Tasos Gogakos; J. Fraser Glickman; Antonio Luz; Antonio Luz; Thomas Tuschl; Thomas Tuschl; Jessica Vincent; Rei Okamoto; Jumpei Aida; ...
    doi: 10.1038/s41467-017-00833-9
    pmc: PMC5622107
    pmid: 28963528
    Publisher: Nature Publishing Group UK
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Posttranscriptional regul... (5R01GM104962-02)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

  • publication . Article . Other literature type . 2016
    Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
    Open Access English
    Authors:
    Dinshaw J. Patel; Jennifer Gebetsberger; Aiming Ren; Aiming Ren; Michael Andreas Juen; Christoph Kreutz; Ronald Micura; Nikola Vušurović; Pu Gao;
    doi: 10.1038/nchembio.2125
    pmc: PMC4990474
    pmid: 27398999
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | Biochemical and structura... (5U19CA179564-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), FWF | Single-molecule FRET inve... (I 1040), FWF | Seeing the invisible &#x9... (P 28725), SNSF | Exploring the function an... (P2BEP3_162061), FWF | Resolving excited states ... (P 26550), NIH | MOUSE GENETICS (2P30CA008748-43)

    The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architect...

3 research outcomes, page 1 of 1