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9 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Avigdor Leftin; Nir Ben-Chetrit; Florian Klemm; Johanna A. Joyce; Jason A. Koutcher;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | Innate Metabolic MRI of M... (5F32CA206277-02), NIH | MOUSE GENETICS (2P30CA008748-43)

    : Iron-deposition is a metabolic biomarker of macrophages in both normal and pathological situations, but the presence of iron in tumor and metastasis-associated macrophages is not known. Here we mapped and quantified hemosiderin-laden macrophage (HLM) deposits in murin...

  • publication . Article . 2009
    Open Access English
    Authors:
    Sean Carlin; Inna Serganova;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1), NIH | Image Analysis and Biosta... (5P50CA086438-08)

    HIF-1alpha is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli. We developed two HIF-1alpha chimeric reporter systems, HIF-...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Leftin, Avigdor; Ben-Chetrit, Nir; Joyce, Johanna A.; Koutcher, Jason A.;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | Innate Metabolic MRI of M... (5F32CA206277-02)

    Abstract Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence  in human cancer, and correlation with immunotherapeuti...

  • publication . Article . 2013
    Open Access
    Authors:
    Ellen Ackerstaff;
    Project: NIH | FUNCTIONAL DISSECTIONS OF... (1F32CA086436-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | In Vivo Image Guidance fo... (5R33CA109772-02), NIH | Memorial Sloan Kettering ... (5U24CA083084-10), NIH | HYPERTHERMIA AND THE FUNC... (5R01CA056909-15)

    Gene-directed enzyme prodrug therapy (GDEPT), or suicide gene therapy, has shown promise in clinical trials. In this preclinical study using stable cell lines and xenograft tumor models, we show that a triple-suicide-gene GDEPT approach produce enhanced therapeutic effi...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Leftin, Avigdor; Zhao, Huiyong; Turkekul, Mesru; de Stanchina, Elisa; Manova, Katia; Koutcher, Jason A.;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | Innate Metabolic MRI of M... (5F32CA206277-02)

    Abstract Immune cells such as macrophages are drivers and biomarkers of most cancers. Scoring macrophage infiltration in tumor tissue provides a prognostic assessment that is correlated with disease outcome and therapeutic response, but generally requires invasive biops...

  • publication . Article . 2009
    Open Access English
    Authors:
    Jenghwa Chang; Bixiu Wen; Peter Kazanzides; Pat Zanzonico; Ronald D. Finn; Gabor Fichtinger; C. Clifton Ling;
    Publisher: AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NSF | ERC: Engineering Research... (9731748), NIH | Multimodality Biological ... (1R01CA084596-01A2), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)
  • publication . Article . 2018
    Open Access English
    Authors:
    Leftin, Avigdor; Koutcher, Jason A.;
    Publisher: Hindawi-Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | Innate Metabolic MRI of M... (5F32CA206277-02)

    <jats:p>Magnetic resonance imaging applications utilizing nanoparticle agents for polarized macrophage detection are conventionally analyzed according to iron-dependent parameters averaged over large regions of interest (ROI). However, contributions from macrophage iron...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Joseph A O'Donoghue; Sean Carlin;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Background: Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistributi...

  • publication . Article . 2015
    Open Access English
    Authors:
    Simões, Rui V.; Serganova, Inna S.; Kruchevsky, Natalia; Leftin, Avigdor; Shestov, Alexander A.; Thaler, Howard T.; Sukenick, George; Locasale, Jason W.; Blasberg, Ronald G.; Koutcher, Jason A.; ...
    Publisher: Neoplasia Press
    Project: NIH | Imaging and Targeting Met... (4R01CA172846-04), NIH | Mechanisms of Metastasis ... (5P01CA094060-07), NIH | Tumor Hypoxia Imaging - L... (1P01CA115675-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterization of the S... (5R01CA193256-02)

    Cancer cells adapt their metabolism during tumorigenesis. We studied two isogenic breast cancer cells lines (highly metastatic 4T1; nonmetastatic 67NR) to identify differences in their glucose and glutamine metabolism in response to metabolic and environmental stress. D...

9 research outcomes, page 1 of 1
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