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5 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Vanni Bucci; Matthew Wipperman;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Pharmacology (1U19AI111143-01), NIH | Mathematical modeling fro... (1R15AI112985-01A1), NSF | ABI Innovation: A new com... (1458347), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (3UL1TR000457-08S1), NIH | Research Training Program... (5D43TW010062-02)

    Abstract Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of broad spectrum...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Emily Hodges;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Clinical and Translationa... (3UL1TR000457-08S1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | COMPREHENSIVE CANCER CENT... (2P30CA016359-15), NIH | Administrative Core (5P50CA140146-04), NIH | Mutant EGF Receptor-Depen... (5R01CA120247-09)

    <jats:p>Genetically-engineered mouse models (GEMMs) of cancer are increasingly being utilized to assess putative driver mutations identified by large scale sequencing of human cancer genomes. In order to accurately interpret experiments that introduce additional mutatio...

  • publication . Article . 2014
    Open Access
    Authors:
    Deri Melissa A.; Ponnala Shashikanth; Zeglis Brian M.; Pohl Gabor; Dannenberg J. J.; Lewis Jason S.; Francesconi Lynn C.;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Zirconium-89: Radiochemis... (1F31CA180360-01), NIH | Clinical and Translationa... (3UL1TR000457-08S1), NSF | IGERT: Returning the Radi... (0965983), NIH | ANIMAL NMR AND RADIONUCLI... (3R24CA083084-04S1)

    Zirconium-89 is an effective radionuclide for antibody-based positron emission tomography (PET) imaging because its physical half-life (78.41 h) matches the biological half-life of IgG antibodies. Desferrioxamine (DFO) is currently the preferred chelator for 89Zr4+; how...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Anton G. Henssen; Richard Koche; Jiali Zhuang; Eileen Jiang; Casie Reed; Amy Eisenberg; Eric Still; Ian C. MacArthur; Elias Rodríguez-Fos; Santiago Gonzalez; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Administrative Core (5P50CA140146-04), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title><jats:p>Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the <jats:italic>piggyBac transposable element derived 5</jats:italic> (<jats:italic>PGBD5</...

5 research outcomes, page 1 of 1
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