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4 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Scott A. Armstrong; Scott A. Armstrong; Eric Still; Richard Koche; Alex Kentsis; Alex Kentsis; Anton G. Henssen; Anton G. Henssen; Elias Rodriguez-Fos; Ian C. MacArthur; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Administrative Core (5P50CA140146-04), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Clinical and Translationa... (3UL1TR000457-08S1)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Preprint . Article . Other literature type . 2016
    Open Access English
    Authors:
    Anton G. Henssen; Alex Kentsis; Alex Kentsis; Daniel E. Bauer; Mithat Gönen; Scott A. Armstrong; Scott A. Armstrong; Luca Pinello; Eileen Jiang; Richard Koche; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Epigenetic regulation of ... (4K08DK093705-05), NIH | Discovering disease-causa... (5K99HG008399-02), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p><jats:bold>Background.</jats:bold> Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities o...

  • publication . Article . 2017
    Open Access
    Authors:
    Sagar Chhangawala; Alex Kentsis; Alex Kentsis; Mojdeh Shakiba; Paolo Cifani;
    Project: NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant signaling in acu... (5R01CA204396-03)

    Background High-accuracy mass spectrometry enables near comprehensive quantification of the components of the cellular proteomes, increasingly including their chemically modified variants. Likewise, large-scale libraries of quantified synthetic peptides are becoming ava...

  • publication . Preprint . Article . Other literature type . 2015
    Open Access
    Authors:
    Cédric Feschotte; Anton G. Henssen; Alex Kentsis; Melissa Burns; Eric Still; Mondira Ray; Amy Eisenberg; Jorge Gandara; Christopher E. Mason; Eileen Jiang; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02)

    eLife digest Transposons are mobile genetic elements that can be cut out of and inserted into DNA. They are present in most living things and make up almost half of the human genome. Transposons help to rearrange and increase the variety of DNA sequences, which can driv...

4 research outcomes, page 1 of 1