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2 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    PGBD5 promotes site-specific oncogenic mutations in human tumors
    Open Access
    Authors:
    Scott A. Armstrong; Scott A. Armstrong; Eric Still; Richard Koche; Alex Kentsis; Alex Kentsis; Anton G. Henssen; Anton G. Henssen; Elias Rodriguez-Fos; Ian C. MacArthur; ...
    doi: 10.1038/ng.3866 , 10.17863/cam.12808
    pmc: PMC5489359
    View all 5 identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Conference object . Preprint . 2017
    Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors
    Open Access
    Authors:
    Casie Reed; Elizabeth Mullen; Scott A. Armstrong; Cristina R. Antonescu; Zhiping Weng; Stephen P. Jackson; Andrew N. Blackford; Richard Koche; Alex Kentsis; Catherine Reeves; ...
    doi: 10.1055/s-0037-1602202 , 10.1101/111138
    Publisher: Georg Thieme Verlag KG
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title><jats:p>Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the <jats:italic>piggyBac transposable element derived 5</jats:italic> (<jats:italic>PGBD5</...

2 research outcomes, page 1 of 1