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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Elias Rodriguez-Fos; Anton Henssen; David Torrents; Ian C MacArthur; Richard Koche; Stephen Philip Jackson; Santiago Gonzalez Rosado;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | Administrative Core (5P50CA140146-04)

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Preprint . 2016
    Open Access
    Authors:
    Brown, Fiona C.; Cifani, Paolo; Drill, Esther; He, Jie; Still, Eric; Zhong, Shan; Balasubramanian, Sohail; Pavlick, Dean; Yilmazel, Bahar; Knapp, Kristina M.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Children's Oncology Group... (5U10CA180899-04)

    <jats:title>Abstract</jats:title><jats:p>Despite intense efforts, the cure rates of children and adults with AML remain unsatisfactory in large part due to resistance to chemotherapy. Whilst cytogenetic risk stratification proved valuable in identifying causes of therap...

  • publication . Article . Preprint . Other literature type . 2015
    Open Access
    Authors:
    Anton G Henssen; Elizabeth Henaff; Eileen Jiang; Amy R Eisenberg; Julianne R Carson; Camila M Villasante; Mondira Ray; Eric Still; Melissa Burns; Jorge Gandara; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02)

    eLife digest Transposons are mobile genetic elements that can be cut out of and inserted into DNA. They are present in most living things and make up almost half of the human genome. Transposons help to rearrange and increase the variety of DNA sequences, which can driv...

  • publication . Preprint . Article . Other literature type . 2016
    Open Access English
    Authors:
    Anton Henssen; Richard Koche; Luca Pinello;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Discovering disease-causa... (5K99HG008399-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Epigenetic regulation of ... (4K08DK093705-05), NIH | Aberrant activation of HG... (5K08CA160660-02)

    <jats:title>Abstract</jats:title><jats:p><jats:bold>Background.</jats:bold> Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities o...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Anton G. Henssen; Richard Koche; Jiali Zhuang; Eileen Jiang; Casie Reed; Amy Eisenberg; Eric Still; Ian C. MacArthur; Elias Rodríguez-Fos; Santiago Gonzalez; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Administrative Core (5P50CA140146-04), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title><jats:p>Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the <jats:italic>piggyBac transposable element derived 5</jats:italic> (<jats:italic>PGBD5</...

  • publication . Article . 2017
    Open Access
    Authors:
    Sagar Chhangawala; Alex Kentsis; Paolo Cifani;
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Aberrant signaling in acu... (5R01CA204396-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    Background High-accuracy mass spectrometry enables near comprehensive quantification of the components of the cellular proteomes, increasingly including their chemically modified variants. Likewise, large-scale libraries of quantified synthetic peptides are becoming ava...

6 research outcomes, page 1 of 1
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