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8 research outcomes, page 1 of 1
  • publication . Preprint . 2019
    Open Access
    Authors:
    Lee, Sangkyu; Liang, Xiaolin; Woods, Meghan; Reiner, Anne S.; Thomas, Duncan; Concannon, Patrick; Bernstein, Leslie; Lynch, Charles F.; Boice, John D.; Deasy, Joseph O.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Core-004 (1P01CA196569-01A1), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Interaction of Radiation,... (5R01CA097397-03)

    <jats:title>Abstract</jats:title><jats:p>The purpose of this study is to identify germline single nucleotide polymorphisms (SNPs) that optimally predict radiation-associated contralateral breast cancer (RCBC) and to provide new biological insights into the carcinogenic ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Lene Mellemkjaer; Irene Orlow; Mark Robson; Anne Reiner;
    Publisher: Springer Nature
    Project: NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | Genome-Wide Association S... (5R01CA129639-05), NIH | Interaction of Radiation,... (5R01CA097397-03)

    Several reproductive factors are known to be associated with risk of breast cancer; however, relationships between these factors with risk of second primary asynchronous contralateral breast cancer (CBC) have not been widely studied. The Women’s Environmental, Cancer, a...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Knight, Julia A; Blackmore, Kristina M; Fan, Jing; Malone, Kathleen E; John, Esther M; Lynch, Charles F; Vachon, Celine M; Bernstein, Leslie; Brooks, Jennifer D; Reiner, Anne S; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Mammographic Density and ... (5R01CA168339-03), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Abstract Background Mammographic density (MD) is an established predictor of risk of a first breast cancer, but the relationship of MD to contralateral breast cancer (CBC) risk is not clear, including the roles of age, mammogram timing, and change with treatment. Multiv...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Reiner, Anne S; Lynch, Charles F; Sisti, Julia S; John, Esther M; Brooks, Jennifer D; Bernstein, Leslie; Knight, Julia A; Hsu, Li; Concannon, Patrick; Mellemkjær, Lene; ...
    Publisher: BioMed Central
    Project: NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Abstract Background Previous population-based studies have described first primary breast cancer tumor characteristics and their association with contralateral breast cancer (CBC) risk. However, information on influential covariates such as treatment, family history of ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Brooks, Jennifer D; Comen, Elizabeth A; Reiner, Anne S; Orlow, Irene; Leong, Siok F; Liang, Xiaolin; Mellemkjær, Lene; Knight, Julia A; Lynch, Charles F; John, Esther M; ...
    Publisher: BMC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | Genome-Wide Association S... (5R01CA129639-05)

    Abstract Background Tamoxifen treatment greatly reduces a woman’s risk of developing a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline genetic variation. CYP2D6 is a key enzyme i...

  • publication . Article . 2020
    Open Access English
    Authors:
    Sangkyu Lee; Xiaolin Liang; Meghan Woods; Anne S. Reiner; Patrick Concannon; Leslie Bernstein; Charles F. Lynch; John D. Boice; Joseph O. Deasy; Jonine L. Bernstein; ...
    Publisher: Public Library of Science
    Project: NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Interaction of Radiation,... (5R01CA097397-03)

    The purpose of this study was to identify germline single nucleotide polymorphisms (SNPs) that optimally predict radiation-associated contralateral breast cancer (RCBC) and to provide new biological insights into the carcinogenic process. Fifty-two women with contralate...

  • publication . Article . 2016
    Open Access
    Authors:
    Lene Mellemkjaer; Patrick Concannon;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02), NIH | Genome-Wide Association S... (5R01CA129639-05), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | Interaction of Radiation,... (5R01CA097397-03)

    Background Treatment with tamoxifen or chemotherapy reduces the risk of contralateral breast cancer (CBC). However, it is uncertain how long the protection lasts and whether the protective effect is modified by patient, tumor, or treatment characteristics. Methods The p...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Lene Mellemkjaer; Patrick Concannon; Roy Shore;
    Publisher: Wiley
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Breast Cancer, Radiation ... (5R01CA114236-02), NIH | Genome-Wide Association S... (5R01CA129639-05), NIH | Interaction of Radiation,... (5R01CA097397-03), NIH | BREAST CANCER, RADIATION ... (5U01CA083178-02)

    Abstract Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)‐negative breast cancer have a fivefold ...

8 research outcomes, page 1 of 1
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