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7 research outcomes, page 1 of 1
  • publication . Article . 2017
    Open Access English
    Authors:
    Elizabeth V Wasmuth; John C Zinder; Dimitrios Zattas; Mom Das; Christopher D Lima;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural and Biochemica... (5F31GM097910-02)

    Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase. Mpp6 interacts with the nine-subunit exosome core, while Rrp47 stabilizes the exoribonuclease Rrp6 a...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher Lima; Shaun Olsen; Michaelyn C. Lux; Zachary Hann;
    Publisher: Proceedings of the National Academy of Sciences
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Rational Design of Adenyl... (5R01GM100477-08), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Tri-Institutional PhD Pro... (1T32GM115327-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Significance Posttranslational protein modification by ubiquitin (Ub) regulates aspects of biology, including protein turnover and the cell cycle. Proteins and enzymes that promote Ub conjugation are therapeutic targets because they are sometimes dysregulated in cancer,...

  • publication . Article . Preprint . Other literature type . 2017
    Open Access
    Authors:
    Christopher Lima; Scott Keeney; Cem Meydan; M. Rhyan Puno;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Isolation of Novel Mutati... (5R37HD035455-18)

    <jats:p>Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, “<jats:italic>ketu</jats:italic>”, caused by a <jats:italic>Ythdc2</jats:italic> missense mutatio...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Laurent Cappadocia; Christopher D. Lima;
    Publisher: American Chemical Society (ACS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Structural Studies of SUM... (5R01GM065872-12)

    Ubiquitin-like proteins (Ubl’s) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin, conjugation is achieved through a cascade of activities that are catalyzed ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Elizabeth Wasmuth; Christopher Lima;
    Publisher: Oxford University Press
    Project: NIH | Structural and Functional... (5R01GM079196-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Structural and Biochemica... (5F31GM097910-02)

    : The eukaryotic RNA exosome is an essential, multi-subunit complex that catalyzes RNA turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core includes 9 subunits that associate with the 3' to 5' exoribonucleases Rrp6, and Rrp44/Dis3, a ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Hann, Zachary S.; Metzger, Meredith B.; Weissman, Allan M.; Lima, Christopher D.;
    Publisher: International Union of Crystallography
    Project: NIH | Structural and Functional... (5R01GM079196-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14)

    A 1.7 Å resolution co-crystal structure of U7BR from Schizosaccharomyces pombe in complex with Ubc7 is reported. Structural comparisons and biochemistry suggest that U7BR presents a steric impediment to E1 binding and inhibits E1-mediated charging, respectively.

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Christopher Lima; Frederick C. Streich Jr.;
    Project: NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01), NIH | Pixel Array Detector for ... (1S10RR029205-01)

    Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin-like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear antigen (P...

7 research outcomes, page 1 of 1
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