Filters (3 )
Download Results
13 research outcomes, page 1 of 2
  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Susanne Kossatz; Giacomo Pirovano; Paula Demétrio De Souza França; Arianna L. Strome; Sumsum P. Sunny; Daniella Karassawa Zanoni; Audrey Mauguen; Brandon Carney; Christian Brand; Veer Shah; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Rapid, quantitative and a... (1R43CA228815-01A1), NIH | Evaluation of PARP1 targe... (1K99CA218875-01A1), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    <jats:title>Abstract</jats:title><jats:p>Major determining factors for survival of patients with oral, oropharyngeal, and esophageal cancer are early detection, the quality of surgical margins, and the contemporaneous detection of residual tumor. Intuitively, the expose...

  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Stephen null; Thomas Reiner; Giacomo Pirovano; Susanne Kossatz;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | Development of a Novel Pe... (5F32EB025050-02), NIH | Evaluation of PARP1 targe... (1K99CA218875-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Rapid, quantitative and a... (1R43CA228815-01A1)

    <jats:title>Abstract</jats:title><jats:p>Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Stephen null; Thomas Reiner;
    Publisher: SpringerOpen
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Core--Pharmacology Facili... (5P30CA091842-05), NIH | IMAGING BIOMARKERS FOR RA... (5R01CA155365-04), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NSF | IGERT: Returning the Radi... (0965983)

    Background Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-processing; despite much rese...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Heiko Schoder; Paula Demetrio De Souza Franca; Reiko Nakajima; Eva Burnazi; Sheryl Roberts; Christian Brand; Milan Grkovski; Audrey Mauguen; Mark P Dunphy; Ronald Ghossein; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    <jats:p>Purpose. We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with 18F-PARPi in patients with head and neck cancer. Patients and Methods. Eleven patients (age 49 to 86 years) with newly diagno...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Thomas Reiner; Susanne Kossatz;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | Development of Nuclear Au... (5R21CA191679-02), NIH | Line-scanned MEMS-based d... (1R01DE023497-01)

    More sensitive and specific methods for early detection are imperative to improve survival rates in oral cancer. However, oral cancer detection is still largely based on visual examination and histopathology of biopsy material, offering no molecular selectivity or spati...

  • publication . Article . 2020
    Open Access English
    Authors:
    Thomas Reiner; Susanne Kossatz; Giacomo Pirovano; Carlos Pérez-Medina;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET nanoreporter image-gu... (1R01CA220234-01A1), NIH | Development of a Novel Pe... (5F32EB025050-02), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    The immune function within the tumor microenvironment has become a prominent therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in immune suppression. We propose an 89Zr-labeled high-density lipoprotein (89Zr-HDL) nanotracer as a means ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Roberts, Sheryl; Andreou, Chrysafis; Choi, Crystal; Donabedian, Patrick; Jayaraman, Madhumitha; Pratt, Edwin C.; Tang, Jun; Pérez-Medina, Carlos; Jason de la Cruz, M.; Mulder, Willem J. M.; ...
    Publisher: Royal Society of Chemistry
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Development of Nuclear Au... (5R21CA191679-02), NIH | Exploring PSMA Biology in... (1R01CA212379-01A1), NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | MRI-Photoacoustic-Raman N... (1R01EB017748-01A1), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    Optoacoustic imaging offers the promise of high spatial resolution and, at the same time, penetration depths well beyond the conventional optical imaging technologies, advantages that would be favorable for a variety of clinical applications. However, similar to optical...

  • publication . Article . 2018
    Open Access English
    Authors:
    Thomas Reiner; Willem Mulder; Carlos Pérez-Medina;
    Publisher: SAGE Publishing
    Project: NIH | A Surface Activable Nanoe... (5R01CA155432-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | Planning and Evaluation (5U54CA137788-03), NIH | Developmental Core (5U54CA132378-03), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1)

    Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DO...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Sheryl Roberts; Eshita Khera; Crystal Choi; Tejas Navaratna; Jan Grimm; Greg M. Thurber; Thomas Reiner;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Maximizing Antibody Drug ... (1R35GM128819-01), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cerenkov luminescence ima... (5R01CA183953-04)

    <jats:title>Abstract</jats:title><jats:p>Limitations in current imaging tools have long challenged the imaging of small pancreatic islets in animal models. Here, we report the first development and in vivo validation testing of a broad spectrum and high absorbance near ...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Strome, Arianna; Kossatz, Susanne; Zanoni, Daniella Karassawa; Rajadhyaksha, Milind; Patel, Snehal; Reiner, Thomas;
    Publisher: SAGE Publications
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | Evaluation of PARP1 targe... (1K99CA218875-01A1)

    Oral cancer is one of the most common cancers globally. Survival rates for patients are directly correlated with stage of diagnosis; despite this knowledge, 60% of individuals are presenting with late-stage disease. Currently, the initial evaluation of a questionable le...

13 research outcomes, page 1 of 2
Last index information