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6 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    David Mazaud; Benjamin Kottler; Catarina Gonçalves-Pimentel; Sandra Proelss; Nadine Tüchler; Celine Deneubourg; Yoshihiro Yuasa; Celine Diebold; Heinz Jungbluth; Eric C. Lai; ...
    Publisher: Society for Neuroscience
    Project: RCUK | Molecular mechanisms of T... (MR/L010666/1), RCUK | Drosophila as a model to ... (NC/L000199/1), RCUK | Mechanisms of action init... (BB/N001230/1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    <p>The fruitfly Drosophila melanogaster has been extensively used as a genetic model for the maintenance of nervous system's functions. Glial cells are of utmost importance in regulating the neuronal functions in the adult organism and in the progression of neurological...

  • publication . Article . 2017
    Open Access English
    Authors:
    Eric Lai; Jiayu Wen;
    Publisher: BMC
    Project: NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOLECULAR ANALYSIS OF THE... (1F32GM013039-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    Background Drosophila melanogaster has one of best-described transcriptomes of any multicellular organism. Nevertheless, the paucity of 3′-sequencing data in this species precludes comprehensive assessment of alternative polyadenylation (APA), which is subject to broad ...

  • publication . Article . 2017
    Open Access English
    Authors:
    Joshua Kavaler; Hong Duan; Rajaguru Aradhya; Luis F. de Navas; Brian Joseph; Boris Shklyar; Eric C. Lai;
    Publisher: The Rockefeller University Press
    Project: NIH | BEN factors are conserved... (5R01NS074037-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06), NIH | Non-canonical miRNA bioge... (2R01GM083300-06)

    Large-scale knockout studies suggest that most miRNAs are phenotypically dispensable. However, Kavaler et al. show here that developmental specification toward a non-neuronal fate in the Drosophila melanogaster peripheral sensory organ lineage depends critically on mir-...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Samie Jaffrey; Eric Lai; Shu Kondo;
    Publisher: Nature Publishing Group
    Project: NSF | Role of nucleoside modifi... (1412379), NIH | Intercellular Communicati... (1R01GM072562-01A2), NSF | Molecular mechanism of Lg... (1052333), NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BEN factors are conserved... (5R01NS074037-02), NIH | Mechanism and regulation ... (2R01NS083833-06), NIH | mRNA methylation: A novel... (5R01DA037150-03)

    N 6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determ...

  • publication . Article . Preprint . 2020
    Open Access
    Authors:
    Garaulet, Daniel L.; Zhang, Binglong; Wei, Lu; Li, Elena; Lai, Eric C.;
    Publisher: Elsevier BV
    Project: NIH | Non-canonical miRNA bioge... (2R01GM083300-06), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06)

    <jats:title>Summary</jats:title><jats:p>How are diverse regulatory strategies integrated to impose appropriately patterned gene expression that underlie <jats:italic>in vivo</jats:italic> phenotypes? Here, we reveal how coordinated miRNA regulation and neural-specific a...

  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Malin Ueberschär; Jiayu Wen; Shu Kondo; Qi Dai; Eric Lai;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic regulatory mechan... (1R35GM126975-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | BEN factors are conserved... (5R01NS074037-02), NIH | Mechanism and regulation ... (2R01NS083833-06)

    The Drosophila genome encodes three BEN-solo proteins including Insensitive (Insv), Elba1 and Elba2 that possess activities in transcriptional repression and chromatin insulation. A fourth protein—Elba3—bridges Elba1 and Elba2 to form an ELBA complex. Here, we report co...

6 research outcomes, page 1 of 1
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