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  • publication . Other literature type . Article . 2015
    Open Access
    Omar Abdel-Wahab; Andrei V. Krivtsov; Neil L. Kelleher; Ari Melnick; Ouathek Ouerfelli; Benjamin H. Durham; Elisa de Stanchina; Gil Blum; Heike Keilhack; Alan Chramiec; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Investigation of the Role... (1F31CA180642-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Profile substrates and in... (1R01GM096056-01)

    The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 and ASXL1 are mutated in distinct cancer types, consistent with independent roles in regulating epig...

1 research outcomes, page 1 of 1