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10 research outcomes, page 1 of 1
  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; ...
    Publisher: Nature Publishing Group
    Project: NIH | The Vanderbilt Institute ... (6UL1TR000445-11), NIH | Discovery and verificatio... (5R01CA189184-04), NHMRC | Markers of androgen actio... (450104), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | Cancer Risk Reduction and... (2R37CA070867-12), NIH | Genes contributing for ni... (5R01DA017932-07), NIH | Consortium Study to Ident... (5R01CA148667-05), NIH | Career Development (Ingle... (5P50CA116201-08), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098710-06),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Estrid Høgdall; Allan Jensen; Usha Menon;
    Project: NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN055424-007), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01PC067001-001), NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | Steroid Hormone Genes and... (5R01CA112523-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1), NIH | Identifying Ovarian Cance... (1R01CA141154-01A2), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | Genes, Hormones &Environm... (5R01CA054419-14), NIH | University of Michigan Co... (3P30CA046592-20S2),...

    OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a pooled analysis of 906 women with ovarian carcino...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Thilo Dörk; Stuart MacGregor; Sara Olson; Anna Jakubowska; Liisa M Pelttari; Susan Ramus; Tomasz Kluz; Ian Campbell; Jolanta Lissowska; Yi Lu; ...
    Publisher: eScholarship, University of California
    Project: NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | Steroid Hormone Genes and... (5R01CA112523-03), NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Ovarian Cancer and Gonado... (5R03CA115195-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | MOUSE GENETICS (2P30CA008748-43),...

    BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potenti...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Alice Lee; Penelope Webb; Allan Jensen; Signe Marie Jensen; Estrid Høgdall; Susan Ramus; Stacey Winham; Usha Menon; Lambertus Kiemeney;
    Publisher: Elsevier BV
    Project: NIH | Training Grant in Genomic... (5T32ES013678-05), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | CASE CONTROL STUDY OF OVA... (5R01CA074850-05), NIH | NORTHERN CALIFORNIA COOPE... (5U01CA069417-02), NIH | DNA POLYMORPHISMS IN OVAR... (5R01CA080742-04),...

    PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for this. However, only a limited number of studies h...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Glubb, Dylan M; Johnatty, Sharon E; Quinn, Michael CJ; O'Mara, Tracy A; Tyrer, Jonathan; Gao, Bo; Fasching, Peter A; Beckmann, Matthias W; Lambrechts, Diether; Vergote, Ignace; ...
    Publisher: Impact Journals
    Project: EC | COGS (223175), NIH | Inflammation and Ovarian ... (5R01CA095023-03), NIH | Regulatory T Cell Functio... (5R01CA126841-04), NIH | Discovery Expansion and R... (5U19CA148065-04), NHMRC | Australasian Biospecimen ... (628903), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05), NIH | The Mitochondrial Genome ... (5R01CA149429-05),...

    We previously identified associations with ovarian cancer outcome at five genetic loci. To identify putatively causal genetic variants and target genes, we prioritized two ovarian outcome loci (1q22 and 19p12) for further study. Bioinformatic and functional genetic anal...

  • publication . Article . 2019
    Open Access English
    Authors:
    Kim, S.; Wang, M.; Tyrer, J. P.; Jensen, A.; Wiensch, A.; Liu, G.; Lee, A. W.; Ness, R. B.; Salvatore, M.; Tworoger, S. S.; ...
    Project: NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NIH | PCOS, Type II diabetes an... (5K22CA193860-03), NIH | Training Grant in Genomic... (5T32ES013678-05), NIH | Steroid Hormone Genes and... (5R01CA112523-03), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | SURVEILLANCE, EPIDEMIOLOG... (N01CN067001-000), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | RISK FACTORS AND PROGNOST... (1R01CA061107-01), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01PC067010-000),...

    As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The intera...

  • publication . Article . 2016
    Open Access
    Authors:
    Permuth, J. B.; Reid, B.; Earp, M.; Chen, Y. A.; Monteiro, A. N. A.; Chen, Z.; Chenevix-Trench, G.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; ...
    Project: NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | Premenopausal Hormone Lev... (5R01CA067262-08), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Molecular Epidemiology of... (400281), NIH | Genetic Epidemiology of O... (5K07CA143047-02), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NHMRC | Epidemiology of Chronic D... (209057), NIH | Mayo Clinic SPORE in Ovar... (3P50CA136393-05S1), NHMRC | Towards cancer control: P... (199600), NIH | COLLABORATIVE STUDY OF OV... (5R01CA058598-05),...

    RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypo...

  • publication . Article . 2018
    Open Access English
    Authors:
    Dixon-Suen, Suzanne C.; Nagle, Christina M.; Thrift, Aaron P.; Pharoah, Paul D. P.; Ewing, Ailith; Pearce, Celeste Leigh; Zheng, Wei; Chenevix-Trench, Georgia; Fasching, Peter A.; Beckmann, Matthias W.; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | USC CANCER CENTER EPIDEMI... (2P01CA017054-17), NIH | HEREDITARY BREAST CANCER-... (5R01CA058860-02), NIH | Ovarian Cancer and Gonado... (5R03CA115195-02), NIH | ROSWELL PARK MEMORIAL INS... (5P30CA016056-17), NIH | Phytoestrogens, alcohol, ... (1K07CA095666-01A1), NIH | PRE SURGICAL O6 BENZYLGUA... (3M01RR000056-38S3), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN067010-000), NIH | MOUSE GENETICS (2P30CA008748-43), NHMRC | Generating the evidence t... (1073898), EC | COGS (223175),...

    Background:\ud \ud Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.\ud M...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun; Lee, Alice W; Wu, Anna H; Bandera, Elisa V; Jensen, Allan; Rossing, Mary Anne; Moysich, Kirsten B; Chang-Claude, Jenny; ...
    Publisher: Oxford University Press
    Project: NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), NIH | Mayo Comprehensive Cancer... (3P30CA015083-37S2), NIH | RISK FACTORS AND PROGNOST... (1R01CA061107-01), NIH | CANCER CENTER SUPPORT GRA... (3P30CA072720-07S2), NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | MOUSE GENETICS (2P30CA008748-43), NSF | Set based tests for genet... (1406712), NHMRC | Molecular Epidemiology of... (400281), NHMRC | Towards cancer control: P... (199600),...

    There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances statistical power for testing multiplicat...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kelemen, Linda E; Earp, Madalene; Fridley, Brooke L; Chenevix-Trench, Georgia; Australian Ovarian Cancer Study Group,; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Hein, Alexander; Lambrechts, Diether; ...
    Publisher: eScholarship, University of California
    Project: NIH | MOLECULAR EPIDEMIOLOGY OF... (5R01CA076016-04), NIH | SURVEILLANCE EPIDEMIOLOGY... (N01CN025403-000), NIH | Epidemiology of Ovarian C... (5R01CA087538-02), NIH | INTERNAL COUNCIL FOR TOBA... (1R01CA087696-01), NIH | Obesity in ovarian cancer... (5K22CA138563-02), NIH | Haplotype-Based Genome Sc... (1R01CA114343-01A2), NIH | Risk Factors for Breast C... (5R01CA050385-18), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MHC-Restricted and MHC-No... (1P50CA159981-01A1),...

    95% CI = 1.03–1.24

10 research outcomes, page 1 of 1
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