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8 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Wang, Dali; Lu, Zheng; Xu, Yichi; Wang, Zi; Santella, Anthony; Bao, Zhirong;
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Systematic Multi-scale An... (5R01GM097576-07)

    Cell shapes provide crucial biological information on complex tissues. Different cell types often have distinct cell shapes, and collective shape changes usually indicate morphogenetic events and mechanisms. The identification and detection of collective cell shape chan...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Fan, Li; Kovacevic, Ismar; Heiman, Maxwell G; Bao, Zhirong;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | ZP Domain Proteins and Ep... (5R01GM108754-04), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | WormGuides: a resource fo... (3R24OD016474-02S1)

    <jats:p>Coordination of neurite morphogenesis with surrounding tissues is crucial to the establishment of neural circuits, but the underlying cellular and molecular mechanisms remain poorly understood. We show that neurons in a C. elegans sensory organ, called the amphi...

  • publication . Article . 2016
    Open Access
    Authors:
    Wang Zi; Ramsey Benjamin J.; Wang Dali; Wong Kwai; Li Husheng; Wang Eric; Bao Zhirong;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Systematic Multi-scale An... (5R01GM097576-07)

    : With cutting-edge live microscopy and image analysis, biologists can now systematically track individual cells in complex tissues and quantify cellular behavior over extended time windows. Computational approaches that utilize the systematic and quantitative data are ...

  • publication . Other literature type . Article . Preprint . 2018
    Open Access
    Authors:
    Zi Wang; Dali Wang; Chengcheng Li; Yichi Xu; Husheng Li; Zhirong Bao;
    Publisher: Oxford University Press (OUP)
    Project: NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | MOUSE GENETICS (2P30CA008748-43)

    Cell movement in the early phase of C. elegans development is regulated by a highly complex process in which a set of rules and connections are formulated at distinct scales. Previous efforts have shown that agent-based, multi-scale modeling systems can integrate physic...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Wang, Dali; Lu, Zheng; Bao, Zhirong;
    Project: NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | MOUSE GENETICS (2P30CA008748-43)

    The detection of cell shape changes in 3D time-lapse images of complex tissues is an important task. However, it is a challenging and tedious task to establish a comprehensive dataset to improve the performance of deep learning models. In the paper, we present a deep le...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Teng Fei;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | IMMUNOLOGICAL MEMORY TO V... (3U19AI057266-05S1), NIH | Bayesian Network Biomarke... (5R01GM124061-02)

    <jats:title>Summary</jats:title><jats:p>In multicellular organisms, a single zygote develops along divergent lineages to produce distinct cell types. What governs these processes is central to the understanding of cell fate specification and stem cell engineering. Here ...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Barnes, Kristopher; Fan, Li; Moyle, Mark W.; Brittin, Christopher; Xu, Yichi; Colón-Ramos, Daniel; Santella, Anthony; Bao, Zhirong;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Molecular and cellular me... (3F32NS098616-01S1), NIH | WormGuides: a resource fo... (3R24OD016474-02S1)

    <jats:title>Abstract</jats:title><jats:p>The internalization of the central nervous system, termed neurulation in vertebrates, is a critical step in embryogenesis. Open questions remain as to how force propels coordinated tissue movement during the process, and little i...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Leighton Duncan; Talley Lambert;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Systematic Multi-scale An... (5R01GM097576-07), NIH | Molecular and cellular me... (3F32NS098616-01S1), NIH | WormGuides: a resource fo... (3R24OD016474-02S1)

    <jats:title>Abstract</jats:title><jats:p>We describe theoretical and practical advances in algorithm and software design, resulting in ten to several thousand-fold faster deconvolution and multiview fusion than previous methods. First, we adapt methods from medical imag...

8 research outcomes, page 1 of 1
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