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9 research outcomes, page 1 of 1
  • publication . Article . 2014
    Open Access
    Authors:
    Wolfgang A. Weber; Susan M. Clardy; Dalya Abdel-Atti; Thomas Reiner; Christian Brand; Edmund J. Keliher; Sean Carlin; Jason S. Lewis; Yachao Zhang;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Accurate visualization and quantification of β-cell mass is critical for the improved understanding, diagnosis, and treatment of both type 1 diabetes (T1D) and insulinoma. Here, we describe the synthesis of a bimodal imaging probe (PET/fluorescence) for imaging GLP-1R e...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Thomas Reiner; Wolfgang A. Weber; Christian Brand; Beatriz Salinas; Christopher Irwin; Yasiri Portorreal; Pooja Desai; Yachao Zhang;
    Publisher: Neoplasia Press, Inc. Published by Elsevier Inc.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    AbstractNew intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Willem J. M. Mulder; Max L. Senders; Hannah Groenen; Cuihua Wang; Jacob M. Hooker; Gabriel Courties; Filip K. Swirski; Carlos Pérez-Medina; Matthias Nahrendorf; Ralph Weissleder; ...
    Publisher: Nature Publishing Group
    Project: NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here...

  • publication . Article . 2016
    Open Access
    Authors:
    Dalya Abdel-Atti; Zahi A. Fayad; Thomas Reiner; Thomas Reiner; Yiming Zhao; Willem J. M. Mulder; Jason S. Lewis; Jason S. Lewis; Carlos Pérez-Medina; Carlos Pérez-Medina; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | A Surface Activable Nanoe... (5R01CA155432-02), NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NWO | Persistent luminescence a... (2300167116), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patient...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Wolfgang A. Weber; Wolfgang A. Weber; Susanne Kossatz; Thomas Reiner; Thomas Reiner;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    Targeting and inhibiting DNA repair pathways is a powerful strategy of controlling malignant growth. One such strategy includes the inhibition of PARP1, a central element in the intracellular DNA damage response. To determine and visualize the expression and intercellul...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Jacob L. Houghton; Paul Kozlowski; Wolfgang W. Scholz; Dalya Abdel-Atti; Thomas Reiner; Brian M. Zeglis; Jan-Philip Meyer; Jason S. Lewis; Naga Vara Kishore Pillarsetty;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Characterization of human... (2R42CA128362-02), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Developing an Anti-sialyl... (5F32CA180452-03), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA1...

  • publication . Article . 2015
    Open Access English
    Authors:
    Nagavarakishore Pillarsetty; Susanne Kossatz; Wolfgang A. Weber; Wolfgang A. Weber; Christopher Irwin; Thomas Reiner; Thomas Reiner; Alexander Bolaender; Beatriz Salinas; Gabriela Chiosis;
    Publisher: Springer Nature
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Background Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Wolfgang A. Weber; Christian Brand; Andreas Paulus; Thomas Reiner; Thomas Reiner; Pooja Desai; Giuseppe Carlucci; Brandon Carney; Brandon Carney;
    Publisher: Springer Nature
    Project: NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NSF | IGERT: Returning the Radi... (0965983), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Clinical and Translationa... (4TL1TR000459-10)

    Background Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible with whole-body imaging techniques. The design of nov...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Susanne Kossatz; Thomas Reiner; Thomas Reiner; Wolfgang A. Weber; Wolfgang A. Weber; Christian Brand; Nancy Y. Lee; Jonathan T. C. Liu; Mithat Gonen; Stanley Gutiontov;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Line-scanned MEMS-based d... (1R01DE023497-01), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Earlier and more accurate detection of oral squamous cell carcinoma (OSCC) is essential to improve the prognosis of patients and to reduce the morbidity of surgical therapy. Here, we demonstrate that the nuclear enzyme Poly(ADP-ribose)Polymerase 1 (PARP1) is a promising...

9 research outcomes, page 1 of 1