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4 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Susanne Kossatz; Thomas Reiner; Thomas Reiner; Wolfgang A. Weber; Wolfgang A. Weber; Christian Brand; Nancy Y. Lee; Jonathan T. C. Liu; Mithat Gonen; Stanley Gutiontov;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Line-scanned MEMS-based d... (1R01DE023497-01), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Earlier and more accurate detection of oral squamous cell carcinoma (OSCC) is essential to improve the prognosis of patients and to reduce the morbidity of surgical therapy. Here, we demonstrate that the nuclear enzyme Poly(ADP-ribose)Polymerase 1 (PARP1) is a promising...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Willem J. M. Mulder; Max L. Senders; Hannah Groenen; Cuihua Wang; Jacob M. Hooker; Gabriel Courties; Filip K. Swirski; Carlos Pérez-Medina; Matthias Nahrendorf; Ralph Weissleder; ...
    Publisher: Nature Publishing Group
    Project: NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here...

  • publication . Article . 2016
    Open Access
    Authors:
    Dalya Abdel-Atti; Zahi A. Fayad; Thomas Reiner; Thomas Reiner; Yiming Zhao; Willem J. M. Mulder; Jason S. Lewis; Jason S. Lewis; Carlos Pérez-Medina; Carlos Pérez-Medina; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | PET/MRI to study nanother... (1R01HL125703-01), NIH | A Surface Activable Nanoe... (5R01CA155432-02), NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NWO | Persistent luminescence a... (2300167116), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patient...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Wolfgang A. Weber; Wolfgang A. Weber; Susanne Kossatz; Thomas Reiner; Thomas Reiner;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | MOUSE GENETICS (2P30CA008748-43)

    Targeting and inhibiting DNA repair pathways is a powerful strategy of controlling malignant growth. One such strategy includes the inhibition of PARP1, a central element in the intracellular DNA damage response. To determine and visualize the expression and intercellul...

4 research outcomes, page 1 of 1