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PublicationsOpen AccessMOUSE GENETICSBioorthogonal Strategies for Targe...Bioconjugate Chemistry
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2 research outcomes, page 1 of 1
  • publication . Article . 2014
    In vivo imaging of GLP-1R with a targeted bimodal PET/fluorescence imaging agent.
    Open Access
    Authors:
    Wolfgang A. Weber; Susan M. Clardy; Dalya Abdel-Atti; Thomas Reiner; Christian Brand; Edmund J. Keliher; Sean Carlin; Jason S. Lewis; Yachao Zhang;
    doi: 10.1021/bc500178d
    pmc: PMC4215873
    pmid: 24856928
    Publisher: American Chemical Society (ACS)
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Accurate visualization and quantification of β-cell mass is critical for the improved understanding, diagnosis, and treatment of both type 1 diabetes (T1D) and insulinoma. Here, we describe the synthesis of a bimodal imaging probe (PET/fluorescence) for imaging GLP-1R e...

  • publication . Article . Other literature type . 2015
    (18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry.
    Open Access
    Authors:
    Jacob L. Houghton; Paul Kozlowski; Wolfgang W. Scholz; Dalya Abdel-Atti; Thomas Reiner; Brian M. Zeglis; Jan-Philip Meyer; Jason S. Lewis; Naga Vara Kishore Pillarsetty;
    doi: 10.1021/acs.bioconjchem.5b00504
    pmc: PMC4759614
    pmid: 26479967
    Publisher: American Chemical Society (ACS)
    Project: NIH | Characterization of human... (2R42CA128362-02), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Developing an Anti-sialyl... (5F32CA180452-03), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA1...

2 research outcomes, page 1 of 1