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8 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Thomas Reiner; Susanne Kossatz;
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Radioiodinated Multifunct... (1R01CA204441-01A1), NIH | Development of Nuclear Au... (5R21CA191679-02), NIH | Line-scanned MEMS-based d... (1R01DE023497-01)

    More sensitive and specific methods for early detection are imperative to improve survival rates in oral cancer. However, oral cancer detection is still largely based on visual examination and histopathology of biopsy material, offering no molecular selectivity or spati...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Naga Vara Kishore Pillarsetty; Jason Lewis;
    Publisher: American Chemical Society (ACS)
    Project: NIH | Characterization of human... (2R42CA128362-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | Molecular Imaging: Traini... (1R25CA096945-01), NIH | Pretargeted Radioimmunoth... (4R00CA178205-02), NIH | Developing an Anti-sialyl... (5F32CA180452-03)

    A first-of-its-kind 18F pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) is presented. As proof-of-principle, a TCO-bearing immunoconjugate of the anti-CA1...

  • publication . Article . 2015
    Open Access
    Authors:
    Naga Vara Kishore Pillarsetty; Thomas Reiner;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Background Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part ...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Giuseppe Carlucci; Andreas Paulus; Thomas Reiner; Christian Brand;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (4TL1TR000459-10), NSF | IGERT: Returning the Radi... (0965983), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Background Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible with whole-body imaging techniques. The design of nov...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Christian Brand; Thomas Reiner;
    Publisher: Elsevier BV
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    AbstractNew intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Willem Mulder; Carlos Pérez-Medina; Gabriel Courties; null null; Max Senders; Gregory R Wojtkiewicz; Jacob Hooker; Thomas Reiner; francois fay; Filip Swirski;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here...

  • publication . Article . 2016
    Open Access
    Authors:
    Jason Lewis; Thomas Reiner; Jun Tang; Willem Mulder; Carlos Pérez-Medina;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | A Surface Activable Nanoe... (5R01CA155432-02), NIH | Anti-inflammatory nanopar... (1R01HL118440-01A1), NIH | Bioorthogonal Strategies ... (1K25EB016673-01), NIH | PET/MRI to study nanother... (1R01HL125703-01), NWO | Persistent luminescence a... (2300167116)

    The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patient...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Thomas Reiner;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Bioorthogonal Strategies ... (1K25EB016673-01)

    Targeting and inhibiting DNA repair pathways is a powerful strategy of controlling malignant growth. One such strategy includes the inhibition of PARP1, a central element in the intracellular DNA damage response. To determine and visualize the expression and intercellul...

8 research outcomes, page 1 of 1
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